共 41 条
Polycomb complexes and epigenetic states
被引:237
作者:

Schwartz, Yuri B.
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机构:
Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA

Pirrotta, Vincenzo
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机构:
Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA
机构:
[1] Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA
关键词:
D O I:
10.1016/j.ceb.2008.03.002
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Important advances in the study of Polycomb Group (PcG) complexes in the past two years have focused on the role of this repressive system in programing the genome. Genome-wide analyses have shown that PcG mechanisms control a large number of genes regulating many cellular functions and all developmental pathways. Current evidence shows that, contrary to the classical picture of their role, PcG complexes do not set a repressed chromatin state that is maintained throughout development but have a much more dynamic role. PcG target genes can become repressed or be reactivated or exist in intermediate states. What controls the balance between repression and derepression is a crucial question in understanding development and differentiation in higher organisms.
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页码:266 / 273
页数:8
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