Proteins containing the UBA domain are able to bind to multi-ubiquitin chains

被引：345

作者：

Wilkinson, CRM ^{[1
]}

Seeger, M ^{[1
]}

Hartmann-Petersen, R ^{[1
]}

Stone, M ^{[1
]}

Wallace, M ^{[1
]}

Semple, C ^{[1
]}

Gordon, C ^{[1
]}

机构：

[1] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 10期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/ncb1001-939

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The UBA domain is a motif found in a variety of proteins, some of which are associated with the ubiquitin-proteasome system(1,2). We describe the isolation of a fission-yeast gene, mud1(+), which encodes a UBA domain containing protein that is able to bind multi-ubiquitin chains. We show that the UBA domain is responsible for this activity. Two other proteins containing this motif, the fission-yeast homologues of Rad23 and Dsk2, are also shown to bind multi-ubiquitin chains via their UBA domains. These two proteins are implicated, along with the fission-yeast Pus1(S5a/Rpn10) subunit of the 26 S proteasome, in the recognition and turnover of substrates by this proteolytic complex.

引用

页码：939 / 943

页数：5

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