Detection of neovessels in atherosclerotic plaques of rabbits using dynamic contrast enhanced MRI and 18F-FDG PET

被引:117
作者
Calcagno, Claudia [1 ,2 ]
Cornily, Jean-Christophe [1 ,4 ,5 ]
Hyafil, Fabien [1 ,4 ,5 ]
Rudd, James H. F. [1 ,4 ,5 ]
Briley-Saebo, Karen C. [1 ,2 ,4 ,5 ]
Mani, Venkatesh [1 ,2 ,4 ,5 ]
Goldschlager, Gregg [3 ]
Machac, Josef [1 ]
Fuster, Valentin [4 ,5 ]
Fayad, Zahi A. [1 ,2 ,4 ,5 ]
机构
[1] Mt Sinai Sch Med, Translat & Mol Imaging Inst, New York, NY 10029 USA
[2] Mt Sinai Sch Med, Dept Radiol, New York, NY 10029 USA
[3] Mt Sinai Sch Med, Ctr Comparat Med & Surg, New York, NY 10029 USA
[4] Mt Sinai Sch Med, Zena & Michael A. Wiener Cardiovasc Inst, New York, NY 10029 USA
[5] Mt Sinai Sch Med, Marie Josee & Henry R Kravis Cardiovasc Hlth Ctr, New York, NY 10029 USA
关键词
atherosclerosis; inflammation; neovessels; MRI; PET;
D O I
10.1161/ATVBAHA.108.166173
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective-The association of inflammatory cells and neovessels in atherosclerosis is considered a histological hallmark of high-risk active lesions. Therefore, the development and validation of noninvasive imaging techniques that allow for the detection of inflammation and neoangiogenesis in atherosclerosis would be of major clinical interest. Our aim was to test 2 techniques, black blood dynamic contrast enhanced MRI (DCE-MRI) and 18-fluorine-fluorodeoxyglucose (18F-FDG) PET, to quantify inflammation expressed as plaque neovessels content in a rabbit model of atherosclerosis. Methods and Results-Atherosclerotic plaques were induced in the aorta of 10 rabbits by a combination of 2 endothelial abrasions and 4 months hyperlipidemic diet. Six rabbits underwent MRI during the injection of Gd-DTPA, whereas 4 rabbits were imaged after injection of 18F-FDG with PET. We found a positive correlation between neovessels count in atherosclerotic plaques and (1) Gd-DTPA uptake parameters evaluated by DCE-MRI (r=0.89, P=0.016) and (2) 18F-FDG uptake evaluated by PET (r=0.5, P=0.103 after clustered robust, Huber-White, standard errors analysis). Conclusion-DCE-MRI and 18F-FDG PET may allow for the evaluation of inflammation in atherosclerotic plaques of rabbits. These noninvasive imaging modalities could be proposed as clinical tools in the evaluation of lesion prognosis and monitoring of anti-angiogenic therapies.
引用
收藏
页码:1311 / 1317
页数:7
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