Age-related differences in symptoms and their interference with quality of life in 903 cancer patients undergoing radiation therapy

Objectives: To evaluate the relationship of age with symptoms and interference with daily function and QOL during RT. Design: A prospective observational study. Setting: A university-based radiation oncology department. Participants: 903 cancer patients who received radiation therapy (RI). The mean age was 61 years (18-92) and 41% were >= 65 years. Measurements: A symptom inventory was administered pre- and post-RT. Patients rated 10 symptoms and their interference with daily function and QOL on a Likert scale from 0 (not present) to 10 (as bad as possible). A total symptom score was calculated by adding the ratings of individual symptoms. T-tests, Pearson correlation coefficients, and mixed modeling were used to investigate relationships between symptoms and their interference with daily function and QOL. Results: For older and younger patients, the total symptom score worsened during RT (p's<0.001). There were no differences in the change in total symptom burden and interference with QOL between older and younger patients during RT. After RT, although younger patients reported significantly worse pain (p=0.03), nausea (p<0.01), and sleep disturbance (p<0.01), symptom interference with walking was more severe in older patients (p=0.01). Mixed modeling showed that older age (p=<0.001), time of survey (after RI, p<0.001), and age*time interaction (p<0.001) increased the likelihood of reporting that symptoms interfered with walking. Conclusion: The prevalence of symptoms was similar for older and younger patients during RT. Older patients are more likely to report that symptoms interfere with walking after RT. (C) 2011 Elsevier Ltd. All rights reserved.