A review of the genetic epidemiology of resistance to parasitic disease and atopic asthma: common variants for common phenotypes?

被引：31

作者：

Barnes, KC ^{[1
]}

Grant, AV ^{[1
]}

Gao, PS ^{[1
]}

机构：

[1] Johns Hopkins Univ, Johns Hopkins Asthma & Allergy Ctr, Baltimore, MD 21224 USA

来源：

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY | 2005年 / 5卷 / 05期

关键词：

atopy; genes; parasite;

D O I：

10.1097/01.all.0000182543.37724.7b

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

An inverse relationship between resistance to certain parasitic diseases and measures of atopy and asthma has long been observed. A possible explanation is that genetic determinants which confer protection against detrimental worm burdens are the same determinants involved in atopic asthma. The focus of this review is to consider the potential candidate genes that have been elucidated as part of molecular, genomic and genetic studies of parasite biology, host-parasite interactions and classic genetic epidemiology studies on parasitic disease and allergic asthma. Recent findings: Comparative studies of the Plasmodium and Schistosoma spp. genomes have revealed a number of proteins that are homologous to humans. A number of linkage and association studies on susceptibility/resistance to parasitic diseases, including malaria and schistosomiasis, overlap with associations that have been identified for susceptibility to atopy and asthma. Summary: In response to parasitic approaches in maintaining survival, the human host has evolved genetic adaptations that minimize severe manifestations of disease, which conversely appear to contribute to allergic disease. A clearer understanding of this process will elucidate the complex pathways and mechanisms involved in these traits.

引用

页码：379 / 385

页数：7

共 64 条

[1] A FAMILY OF ERYTHROCYTE BINDING-PROTEINS OF MALARIA PARASITES [J].

ADAMS, JH ;

SIM, BKL ;

DOLAN, SA ;

FANG, XD ;

KASLOW, DC ;

MILLER, LH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (15) :7085-7089

[2] TUMOR-NECROSIS-FACTOR-ALPHA RESTORES GRANULOMAS AND INDUCES PARASITE EGG-LAYING IN SCHISTOSOME-INFECTED SCID MICE [J].

AMIRI, P ;

LOCKSLEY, RM ;

PARSLOW, TG ;

SADICK, M ;

RECTOR, E ;

RITTER, D ;

MCKERROW, JH .

NATURE, 1992, 356 (6370) :604-607

[3] Inverse association between skin response to aeroallergens and Schistosoma mansoni infection [J].

Araujo, MI ;

Lopes, AA ;

Medeiros, M ;

Cruz, AA ;

Sousa-Atta, L ;

Solé, D ;

Carvalho, EM .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2000, 123 (02) :145-148

[4] Recall helper T cell response - T helper 1 cell-resistant allergic susceptibility without biasing uncommitted CD4 T cells [J].

Aronica, MA ;

McCarthy, S ;

Swaidani, S ;

Mitchell, D ;

Goral, M ;

Sheller, JR ;

Boothby, M .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 169 (05) :587-595

[5] DETECTION OF IGE ANTIBODIES TO A WIDE-RANGE OF INSECT SPECIES IN SUBJECTS WITH SUSPECTED INHALANT ALLERGIES TO INSECTS [J].

BALDO, BA ;

PANZANI, RC .

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1988, 85 (03) :278-287

[6] Elevated anti-malarial IgE in asymptomatic individuals is associated with reduced risk for subsequent clinical malaria [J].

Bereczky, S ;

Montgomery, SM ;

Troye-Blomberg, M ;

Rooth, I ;

Shaw, MA ;

Färnert, A .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2004, 34 (08) :935-942

[7]

BLANTON RE, 2005, EUR J HUM GENET

[8]

BOTTINI N, 2005, AM J PHYS ANTHROPOL

[9] The semiconserved head structure of Plasmodium falciparum erythrocyte membrane protein 1 mediates binding to multiple independent host receptors [J].

Chen, QJ ;

Heddini, A ;

Barragan, A ;

Fernandez, V ;

Pearce, SFA ;

Wahlgren, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (01) :1-9

[10] IFN-γ polymorphisms (IFN-γ+2109 and IFN-γ+3810) are associated with severe hepatic fibrosis in human hepatic schistosomiasis (Schistosoma mansoni) [J].

Chevillard, C ;

Moukoko, CE ;

Elwali, NEMA ;

Bream, JH ;

Kouriba, B ;

Argiro, L ;

Rahoud, S ;

Mergani, A ;

Henri, S ;

Gaudart, J ;

Mohamed-Ali, Q ;

Young, HA ;

Dessein, AJ .

JOURNAL OF IMMUNOLOGY, 2003, 171 (10) :5596-5601

← 1 2 3 4 5 6 7 →