Characterization of optical and thermal distributions from an intracranial balloon applicator for photodynamic therapy

被引：13

作者：

Madsen, SJ ^{[1
]}

Svaasand, LO ^{[1
]}

Tromberg, BJ ^{[1
]}

Hirschberg, H ^{[1
]}

机构：

[1] Univ Nevada, Dept Hlth Phys, Las Vegas, NV 89154 USA

来源：

LASER-TISSUE INTERACTION XII: PHOTOCHEMICAL, PHOTOTHERMAL, AND PHOTOMECHANICAL | 2001年 / 4257卷

关键词：

photodynamic therapy; balloon applicator; light distribution; thermal distribution; brain tumor;

D O I：

10.1117/12.434743

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An indwelling balloon applicator developed for postoperative intracavity brachytherapy was evaluated for photodynamic therapy. Measurements of light distributions in a brain phantom show that the applicator can be used to deliver sufficiently uniform light doses during PDT. The light distribution is uniform to within 5% when the balloon is filled with a scattering medium. Based on simple assumptions, it is shown that the applicator can be used to deliver a threshold optical dose to brain tissue at depths of 1.4 cm in less than 90 minutes. A mathematical model of the thermal distribution around the applicator suggests that tissue temperatures will be below the hyperthermic threshold at the input powers required for treatments to depths of 1.4 cm in the resection cavity. The delivery of threshold light doses to depths exceeding 1.4 cm is likely to result in hyperthermic effects to tissues near the applicator surface.

引用

页码：41 / 49

页数：9

共 19 条

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