Non-insulin-dependent diabetes mellitus - A genetically programmed failure of the beta cell to compensate for insulin resistance

被引:462
作者
Polonsky, KS
Sturis, J
Bell, GI
机构
[1] UNIV CHICAGO,DEPT BIOCHEM,CHICAGO,IL 60637
[2] UNIV CHICAGO,DEPT MOLEC BIOL,CHICAGO,IL 60637
[3] UNIV CHICAGO,HOWARD HUGHES MED INST,CHICAGO,IL 60637
关键词
D O I
10.1056/NEJM199603213341207
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:777 / 783
页数:7
相关论文
共 71 条
  • [1] PATHOGENIC ROLE OF AN INSULIN-RECEPTOR DEFECT IN DIABETES-MELLITUS OF OBESE
    BECKNIELSEN, H
    [J]. DIABETES, 1978, 27 (12) : 1175 - 1181
  • [2] GENE FOR NON-INSULIN-DEPENDENT DIABETES-MELLITUS (MATURITY-ONSET DIABETES OF THE YOUNG SUBTYPE) IS LINKED TO DNA POLYMORPHISM ON HUMAN CHROMOSOME-20Q
    BELL, GI
    XIANG, KS
    NEWMAN, MV
    WU, SH
    WRIGHT, LG
    FAJANS, SS
    SPIELMAN, RS
    COX, NJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) : 1484 - 1488
  • [3] PHYSIOLOGIC EVALUATION OF FACTORS CONTROLLING GLUCOSE-TOLERANCE IN MAN - MEASUREMENT OF INSULIN SENSITIVITY AND BETA-CELL GLUCOSE SENSITIVITY FROM THE RESPONSE TO INTRAVENOUS GLUCOSE
    BERGMAN, RN
    PHILLIPS, LS
    COBELLI, C
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1981, 68 (06) : 1456 - 1467
  • [4] BYRNE M, 1995, DIABETES, V44, pA195
  • [5] ALTERED INSULIN SECRETORY RESPONSES TO GLUCOSE IN SUBJECTS WITH A MUTATION IN THE MODY1 GENE ON CHROMOSOME-20
    BYRNE, MM
    STURIS, J
    FAJANS, SS
    ORTIZ, FJ
    STOLTZ, A
    STOFFEL, M
    SMITH, MJ
    BELL, GI
    HALTER, JB
    POLONSKY, KS
    [J]. DIABETES, 1995, 44 (06) : 699 - 704
  • [6] INSULIN SECRETORY ABNORMALITIES IN SUBJECTS WITH HYPERGLYCEMIA DUE TO GLUCOKINASE MUTATIONS
    BYRNE, MM
    STURIS, J
    CLEMENT, K
    VIONNET, N
    PUEYO, ME
    STOFFEL, L
    TAKEDA, J
    PASSA, P
    COHEN, D
    BELL, GI
    VELHO, G
    FROGUEL, P
    POLONSKY, KS
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (03) : 1120 - 1130
  • [7] INSULIN-RECEPTOR KINASE IN HUMAN SKELETAL-MUSCLE FROM OBESE SUBJECTS WITH AND WITHOUT NONINSULIN DEPENDENT DIABETES
    CARO, JF
    SINHA, MK
    RAJU, SM
    ITTOOP, O
    PORIES, WJ
    FLICKINGER, EG
    MEELHEIM, D
    DOHM, GL
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (05) : 1330 - 1337
  • [8] ROLE OF GLUCOSE-TRANSPORT IN THE POSTRECEPTOR DEFECT OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS
    CIARALDI, TP
    KOLTERMAN, OG
    SCARLETT, JA
    KAO, M
    OLEFSKY, JM
    [J]. DIABETES, 1982, 31 (11) : 1016 - 1022
  • [9] OBESE AND DIABETES - 2 MUTANT-GENES CAUSING DIABETES-OBESITY SYNDROMES IN MICE
    COLEMAN, DL
    [J]. DIABETOLOGIA, 1978, 14 (03) : 141 - 148
  • [10] INSULIN SENSITIVITY AND INSULIN BINDING TO MONOCYTES IN MATURITY-ONSET DIABETES
    DEFRONZO, R
    DEIBERT, D
    HENDLER, R
    FELIG, P
    SOMAN, V
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1979, 63 (05) : 939 - 946