Association of hepatitis C virus infection with serum iron status: Analysis of data from the Third National Health and Nutrition Examination Survey

被引:56
作者
Shan, Y
Lambrecht, RW
Bonkovsky, HL
机构
[1] Univ Connecticut, Ctr Hlth, Dept Med, Farmington, CT 06030 USA
[2] Univ Connecticut, Ctr Hlth, Dept Pharmacol, Farmington, CT 06030 USA
[3] Univ Connecticut, Ctr Hlth, Liver Biliary Pancreat Ctr, Farmington, CT 06030 USA
[4] Univ Connecticut, Ctr Hlth, Gen Clin Res Ctr, Farmington, CT 06030 USA
关键词
D O I
10.1086/428062
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. There is growing evidence that mildly increased amounts of iron in the liver can increase hepatic injury, particularly if combined with other hepatotoxic factors, such as alcohol use, use of porphyrogenic drugs, or chronic viral hepatitis. In the present study, the association of hepatitis C virus ( HCV) infection with serum measurements of iron status was assessed in the US population. Methods. We analyzed data from a total of 14,462 participants in the Third National Health and Nutrition Examination Survey. We excluded subjects who were aged < 12 years, subjects for whom measurements of serum levels of iron or ferritin or the results of liver function tests were missing, and subjects who had a serum transferrin saturation of greater than or equal to50% ( to help exclude subjects with hemochromatosis). Results. Mean serum levels of ferritin and iron ( +/- standard error) were significantly higher among subjects with HCV infection ( 100 +/- 3 ng/ mL and 229 +/- 17 mug/dL, respectively) than among subjects without liver disease (83 +/- 0.3 ng/ mL and 101 +/- 2.1 mug/dL, respectively) (P < .0001). Serum levels of ferritin were directly and significantly correlated with serum levels of alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transpeptidase (r= 0.25 r=0.24, r=0.28, respectively; P <.0001), whereas platet counts were inversely correlated with serum levels of ferritin (r = -0.12; P<.0001). Conclusion. HCV infection is significantly associated with higher serum levels of ferritin and iron in the US population.
引用
收藏
页码:834 / 841
页数:8
相关论文
共 55 条
  • [1] Hepatitis C virus infection in the United States
    Alter, MJ
    [J]. JOURNAL OF HEPATOLOGY, 1999, 31 : 88 - 91
  • [2] BARTON AL, 1995, AM J CLIN PATHOL, V103, P419
  • [3] Barton JC, 2000, HEMOCHROMATOSIS GENE
  • [4] Bonkovsky H L, 2000, Clin Liver Dis, V4, P409, DOI 10.1016/S1089-3261(05)70116-1
  • [5] Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis
    Bonkovsky, HL
    Jawaid, Q
    Tortorelli, K
    LeClair, P
    Cobb, J
    Lambrecht, RW
    Banner, BF
    [J]. JOURNAL OF HEPATOLOGY, 1999, 31 (03) : 421 - 429
  • [6] Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C
    Bonkovsky, HL
    Troy, N
    McNeal, K
    Banner, BF
    Sharma, A
    Obando, J
    Mehta, S
    Koff, RS
    Liu, Q
    Hsieh, CC
    [J]. JOURNAL OF HEPATOLOGY, 2002, 37 (06) : 848 - 854
  • [7] Iron in liver diseases other than hemochromatosis
    Bonkovsky, HL
    Banner, BF
    Lambrecht, RW
    Rubin, RB
    [J]. SEMINARS IN LIVER DISEASE, 1996, 16 (01) : 65 - 82
  • [8] Bonkovsky HL, 2002, AM J GASTROENTEROL, V97, P1
  • [9] Iron and chronic viral hepatitis
    Bonkovsky, HL
    Banner, BF
    Rothman, AL
    [J]. HEPATOLOGY, 1997, 25 (03) : 759 - 768
  • [10] Iron reduction as an adjuvant to interferon therapy in patients with chronic hepatitis C who have previously not responded to interferon: A multicenter, prospective, randomized, controlled trial
    Di Bisceglie, AM
    Bonkovsky, HL
    Chopra, S
    Flamm, S
    Reddy, RK
    Grace, N
    Killenberg, P
    Hunt, C
    Tamburro, C
    Tavill, AS
    Ferguson, R
    Krawitt, E
    Banner, B
    Bacon, BR
    [J]. HEPATOLOGY, 2000, 32 (01) : 135 - 138