Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in Taiwan

被引：24

作者：

Chiu, Cheng-Hsun

Su, Lin-Hui

Huang, Yhu-Chering

Lai, Jui-Chia

Chen, Hsiu-Ling

Wu, Tsu-Lan

Lin, Tzou-Yien

机构：

[1] Chang Gung Childrens Hosp, Dept Pediat, Dept Pediat Infect Dis, Tao Yuan, Taiwan

[2] Chang Gung Univ, Coll Med, Tao Yuan, Taiwan

[3] Chang Gung Mem Hosp, Dept Clin Pathol, Tao Yuan, Taiwan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 09期

关键词：

D O I：

10.1128/AAC.01563-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The rate of nonsusceptibility of penicillin-resistant Streptococcus pneumoniae strains to ceftriaxone increased significantly in Taiwan in 2005. Approximately 90% of the ceftriaxone-nonsusceptible isolates were found to be of four major serotypes (serotypes 613, 14, 19F, and 23F). Seven amino acid alterations in the penicillin-binding protein 213 trans peptidase-encoding region specifically contributed to the resistance.

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页码：3404 / 3406

页数：3

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