Synonymous codon selection controls in vivo turnover and amount of mRNA in Escherichia coli bla and ompA genes

被引：25

作者：

Deana, A ^{[1
]}

Ehrlich, R ^{[1
]}

Reiss, C ^{[1
]}

机构：

[1] CNRS,CTR GENET MOLEC,LAB STRUCT & DYNAM GENOME,F-91198 GIF SUR YVETTE,FRANCE

来源：

JOURNAL OF BACTERIOLOGY | 1996年 / 178卷 / 09期

关键词：

D O I：

10.1128/jb.178.9.2718-2720.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A number of silent codon changes were made in two Escherichia coli genes, For the ompA gene, the replacement of seven consecutive frequently used codons with synonymous infrequently used codons reduced the ompA mRNA level and its half-life, For the bla gene, the exchange of 24 codons for the most frequently used synonymous codons extended the bla mRNA half-life. A modification of ribosome traffic could account for these observations.

引用

页码：2718 / 2720

页数：3

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