Nuclear-receptor interactions on DNA-response elements

被引：219

作者：

Khorasanizadeh, S ^{[1
]}

Rastinejad, F

机构：

[1] Univ Virginia, Sch Med, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

[2] Univ Virginia, Sch Med, Dept Pharmacol, Charlottesville, VA 22908 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0968-0004(01)01800-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear receptors regulate transcription by binding to DNA-response elements using their conserved DNA-binding domains, These response elements contain conserved hexameric sequences that can be arranged in various bipartite configurations, including inverted and direct repeats. A series of structural studies on receptor-DNA binding complexes illustrate the strategies used by receptors to recognize the symmetry of their binding site as well as its sequence. These structures also indicate how cooperation between receptors enhances their joint affinity and selectivity for correctly configured sites.

引用

页码：384 / 390

页数：7

共 52 条

[1] CHARACTERIZATION OF THE LIGAND-DEPENDENT TRANSACTIVATION DOMAIN OF THYROID-HORMONE RECEPTOR [J].

BARETTINO, D ;

RUIZ, MDMV ;

STUNNENBERG, HG .

EMBO JOURNAL, 1994, 13 (13) :3039-3049

[2] Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains [J].

Bourguet, W ;

Vivat, V ;

Wurtz, JM ;

Chambon, P ;

Gronemeyer, H ;

Moras, D .

MOLECULAR CELL, 2000, 5 (02) :289-298

[3] Characterization and DNA-binding properties of GRF, a novel monomeric binding orphan receptor related to GCNF and βFTZ-F1 [J].

Charles, JP ;

Shinoda, T ;

Chinzei, Y .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 266 (01) :181-190

[4] Structure of the DNA binding domains from NFAT, Fos and Jun bound specifically to DNA [J].

Chen, L ;

Glover, JNM ;

Hogan, PG ;

Rao, A ;

Harrison, SC .

NATURE, 1998, 392 (6671) :42-48

[5] IDENTIFICATION OF A CONSERVED REGION REQUIRED FOR HORMONE DEPENDENT TRANSCRIPTIONAL ACTIVATION BY STEROID-HORMONE RECEPTORS [J].

DANIELIAN, PS ;

WHITE, R ;

LEES, JA ;

PARKER, MG .

EMBO JOURNAL, 1992, 11 (03) :1025-1033

[6] Structure and specificity of nuclear receptor-coactivator interactions [J].

Darimont, BD ;

Wagner, RL ;

Apriletti, JW ;

Stallcup, MR ;

Kushner, PJ ;

Baxter, JD ;

Fletterick, RJ ;

Yamamoto, KR .

GENES & DEVELOPMENT, 1998, 12 (21) :3343-3356

[7] ACTIVATION FUNCTION-2 (AF-2) OF RETINOIC ACID RECEPTOR AND 9-CIS RETINOIC ACID RECEPTOR - PRESENCE OF A CONSERVED AUTONOMOUS CONSTITUTIVE ACTIVATING DOMAIN AND INFLUENCE OF THE NATURE OF THE RESPONSE ELEMENT ON AF-2 ACTIVITY [J].

DURAND, B ;

SAUNDERS, M ;

GAUDON, C ;

ROY, B ;

LOSSON, R ;

CHAMBON, P .

EMBO JOURNAL, 1994, 13 (22) :5370-5382

[8] THE FUNCTION AND STRUCTURE OF THE METAL COORDINATION SITES WITHIN THE GLUCOCORTICOID RECEPTOR DNA-BINDING DOMAIN [J].

FREEDMAN, LP ;

LUISI, BF ;

KORSZUN, ZR ;

BASAVAPPA, R ;

SIGLER, PB ;

YAMAMOTO, KR .

NATURE, 1988, 334 (6182) :543-546

[9] Asymmetry in the PPARγ/RXRα crystal structure reveals the molecular basis of heterodimerization among nuclear receptors [J].

Gampe, RT ;

Montana, VG ;

Lambert, MH ;

Miller, AB ;

Bledsoe, RK ;

Milburn, MV ;

Kliewer, SA ;

Willson, TM ;

Xu, HE .

MOLECULAR CELL, 2000, 5 (03) :545-555

[10] THE BASIS FOR HALF-SITE SPECIFICITY EXPLORED THROUGH A NONCOGNATE STEROID RECEPTOR-DNA COMPLEX [J].

GEWIRTH, DT ;

SIGLER, PB .

NATURE STRUCTURAL BIOLOGY, 1995, 2 (05) :386-394

← 1 2 3 4 5 6 →