Somatostatin receptor scintigraphy and somatostatin therapy in the evaluation and treatment of malignant thymoma

被引:37
作者
Lin, K
Nguyen, BD
Ettinger, DS
Chin, BB
机构
[1] Johns Hopkins Med Inst, Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA
[2] Johns Hopkins Med Inst, Dept Med Oncol, Baltimore, MD 21287 USA
关键词
thymoma; In-111-octreotide scintigraphy; somatostatin therapy;
D O I
10.1097/00003072-199901000-00006
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: This report illustrates the potential diagnostic and therapeutic utility of somatostatin receptor scintigraphy and therapy with somatostatin. Methods: In-ill pentetreotide (In-ll octreotide), a somatostatin analog, was used to define the receptor status and the extent of disease in a case of malignant thymoma, Results: Subsequent treatment with nonradioactive somatostatin inhibited tumor growth, Conclusion: In-ill octreotide may be usfeul to define tumor receptor status and may provide prognostic information useful in determining subsequent therapy.
引用
收藏
页码:24 / 28
页数:5
相关论文
共 30 条
[1]   CLINICAL EFFICACY OF OCTREOTIDE SCINTIGRAPHY IN PATIENTS WITH MIDGUT CARCINOID-TUMORS AND EVALUATION OF INTRAOPERATIVE SCINTILLATION DETECTION [J].
AHLMAN, H ;
WANGBERG, B ;
TISELL, LE ;
NILSSON, O ;
FJALLING, M ;
FORSSELLARONSSON, E .
BRITISH JOURNAL OF SURGERY, 1994, 81 (08) :1144-1149
[2]  
Bader M, 1996, Recent Results Cancer Res, V142, P137
[3]   INHIBITION OF CELL-PROLIFERATION BY THE SOMATOSTATIN ANALOG RC-160 IS MEDIATED BY SOMATOSTATIN RECEPTOR SUBTYPES SSTR2 AND SSTR5 THROUGH DIFFERENT MECHANISMS [J].
BUSCAIL, L ;
ESTEVE, JP ;
SAINTLAURENT, N ;
BERTRAND, V ;
REISINE, T ;
OCARROLL, AM ;
BELL, GI ;
SCHALLY, AV ;
VAYSSE, N ;
SUSINI, C .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) :1580-1584
[4]  
Buscail L, 1996, CANCER RES, V56, P1823
[5]   STIMULATION OF TYROSINE PHOSPHATASE AND INHIBITION OF CELL-PROLIFERATION BY SOMATOSTATIN ANALOGS - MEDIATION BY HUMAN SOMATOSTATIN RECEPTOR SUBTYPES SSTR1 AND SSTR2 [J].
BUSCAIL, L ;
DELESQUE, N ;
ESTEVE, JP ;
SAINTLAURENT, N ;
PRATS, H ;
CLERC, P ;
ROBBERECHT, P ;
BELL, GI ;
LIEBOW, C ;
SCHALLY, AV ;
VAYSSE, N ;
SUSINI, C .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (06) :2315-2319
[6]  
Debono David J., 1996, Current Opinion in Oncology, V8, P112, DOI 10.1097/00001622-199603000-00007
[7]  
Delesque N, 1997, CANCER RES, V57, P956
[8]  
DELESQUE N, 1995, CIBA F SYMP, V190, P187
[9]  
Janson ET, 1996, CANCER RES, V56, P2561
[10]  
KRENNING EP, 1997, J NUCL MED, V38, pS47P