Viral shedding in children with influenza virus infections treated with neuraminidase inhibitors

被引：74

作者：

Sato, M

Hosoya, M

Kato, K

Suzuki, H

机构：

[1] Fukushima Med Univ, Sch Med, Dept Pediat, Fukushima 9601295, Japan

[2] Fukushima Inst Publ Hlth, Fukushima, Japan

[3] Fukushima S Aizu Hosp, Dept Pediat, Tajima, Japan

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2005年 / 24卷 / 10期

关键词：

influenza; neuraminidase inhibitor; oseltamivir; zanamivir;

D O I：

10.1097/01.inf.0000180976.81055.ce

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the efficacy of neuraminidase inhibitors for reducing the duration of virus shedding after naturally occurring influenza virus infection. The duration of fever was significantly shorter in patients treated with neuraminidase inhibitors than in untreated patients. The durations of vir-us shedding from patients treated with neuraminidase inhibitors were not significantly shorter than those of untreated patients.

引用

页码：931 / 932

页数：2

共 10 条

[1] PATTERNS OF SHEDDING OF MYXOVIRUSES AND PARAMYXOVIRUSES IN CHILDREN [J].

FRANK, AL ;

TABER, LH ;

WELLS, CR ;

WELLS, JM ;

GLEZEN, WP ;

PAREDES, A .

JOURNAL OF INFECTIOUS DISEASES, 1981, 144 (05) :433-441

[2] VIRAL SHEDDING PATTERNS OF CHILDREN WITH INFLUENZA-B INFECTION [J].

HALL, CB ;

DOUGLAS, RG ;

GEIMAN, JM ;

MEAGHER, MP .

JOURNAL OF INFECTIOUS DISEASES, 1979, 140 (04) :610-613

[3] Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza - Randomized controlled trials for prevention and treatment [J].

Hayden, FG ;

Treanor, JJ ;

Fritz, RS ;

Lobo, M ;

Betts, RF ;

Miller, M ;

Kinnersley, N ;

Mills, RG ;

Ward, P ;

Straus, SE .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (13) :1240-1246

[4] Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections [J].

Hayden, FG ;

Osterhaus, ADME ;

Treanor, JJ ;

Fleming, DM ;

Aoki, FY ;

Nicholson, KG ;

Bohnen, AM ;

Hirst, HM ;

Keene, O ;

Wightman, K .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (13) :874-880

[5] Zanamivir for treatment of symptomatic influenza A and B infection in children five to twelve years of age: a randomized controlled trial [J].

Hedrick, JA ;

Barzilai, A ;

Behre, U ;

Henderson, FW ;

Hammond, J ;

Reilly, L ;

Keene, O .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2000, 19 (05) :410-417

[6] Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial [J].

Nicholson, KG ;

Aoki, FY ;

Osterhaus, ADME ;

Trottier, S ;

Carewicz, O ;

Mercier, CH ;

Rode, A ;

Kinnersley, N ;

Ward, P .

LANCET, 2000, 355 (9218) :1845-1850

[7] Zanamivir:: A significant reduction in viral load during treatment in military conscripts with influenza [J].

Puhakka, T ;

Lehti, H ;

Vainionpää, R ;

Jormanainen, V ;

Pulkkinen, M ;

Sharp, S ;

Kerr, C ;

Dempsey, M ;

Ring, CJ ;

Ward, C ;

Tisdale, M .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2003, 35 (01) :52-58

[8]

Silagy C, 1998, LANCET, V352, P1877, DOI 10.1016/S0140-6736(98)10190-3

[9] Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza - A randomized controlled trial [J].

Treanor, JJ ;

Hayden, FG ;

Vrooman, PS ;

Barbarash, R ;

Bettis, R ;

Riff, D ;

Singh, S ;

Kinnersley, N ;

Ward, P ;

Mills, RG .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (08) :1016-1024

[10] Oral oseltamivir treatment of influenza in children [J].

Whitley, RJ ;

Hayden, FG ;

Reisinger, KS ;

Young, N ;

Dutkowski, R ;

Ipe, D ;

Mills, RG ;

Ward, P .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2001, 20 (02) :127-133

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