Simultaneous determination of ethinylestradiol and levonorgestrel in oral contraceptives by derivative spectrophotometry

被引：37

作者：

Berzas, JJ

Rodriguez, J

Castaneda, G

机构：

[1] Departamento de Química Analítica y Tecnología de Alimentos, Facultad de Ciencias, Universidad de Castilla-La Mancha

来源：

ANALYST | 1997年 / 122卷 / 01期

关键词：

ethinylestradiol; levonorgestrel; derivative spectrophotometry; oral contraceptives;

D O I：

10.1039/a604558h

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method for determining ethinylestradiol (ETE) and levonorgestrel (LEV) in mixtures by first-derivative spectrophotometry is described. The procedure does not require any separation step. Measurements are made at the zero-crossing wavelengths and the calibration graphs are linear up to 26 and 33 mu g ml(-1) of ETE and LEV, respectively. The method was applied to the determination of both compounds in five different Spanish commercial low-dose oral contraceptives. Similar results mere obtained by an HPLC method.

引用

页码：41 / 44

页数：4

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