Synthesis of optically active β-benzyl-γ-butyrolactone through lipase-catalyzed kinetic resolution

被引：12

作者：

Caro, Y ^{[1
]}

Masaguer, CF ^{[1
]}

Raviña, E ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Fac Farm, Quim Farmaceut Lab, Dept Quim Organ, E-15782 Santiago De Compostela, Spain

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0957-4166(01)00317-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The lipase-catalyzed kinetic resolution of the racemic gamma -hydroxy ester 2, coupled with subsequent acid-mediated cyclization, is an effective method for the synthesis of both enantiomers of beta -benzyl-gamma -butyrolactone 1. This enzymatic process affords the product with high enantiomeric excess under mild reaction conditions and does not require optically active starting materials. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1723 / 1726

页数：4

共 19 条

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