Improved experimental procedure for the synthesis of the potent MEK inhibitor PD184352

被引：7

作者：

Shpiro, N ^{[1
]}

Marquez, R ^{[1
]}

机构：

[1] Univ Dundee, Sch Life Sci, Div Biol Chem & Mol Microbiol, Dundee DD1 4HN, Scotland

来源：

SYNTHETIC COMMUNICATIONS | 2005年 / 35卷 / 17期

关键词：

inhibitor; hydroxylamines; PD184352;

D O I：

10.1080/00397910500184909

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved synthesis of the potent MEK inhibitor PD184352 (2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide)) is herein reported. This new and reproducible protocol provides a simple and efficient way of generating gram quantities of PD 184352 with minimal purification.

引用

页码：2265 / 2270

页数：6