Gene polymorphisms and transplantation

被引：60

作者：

Akalin, E ^{[1
]}

Murphy, B ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Div Renal, New York, NY 10029 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(00)00261-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The influence of gene polymorphisms in key immunoregulatory molecules on the clinical course post-transplant has become an area of active research, since it offers a possible explanation for the heterogeneity in outcomes between individuals. Several groups have now investigated the association of polymorphisms in molecules - including cytokines, cytokine receptors, adhesion molecules and costimulatory molecules that participate in the immune response to an allograft. Several interesting observations have been made that would suggest that genetic variability influencing allograft survival reaches beyond that of the MHC molecules.

引用

页码：572 / 576

页数：5

共 36 条

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