Electrochemistry of chalcogen compounds: prediction of antioxidant activity

被引：47

作者：

Giles, GI

Tasker, KM

Johnson, RJK

Jacob, C

Peers, C

Green, KN

机构：

[1] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England

[2] Univ Leeds, Inst Cardiovasc Res, Leeds LS2 9JT, W Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 23期

关键词：

D O I：

10.1039/b107972g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis and characterisation of organochalcogens has demonstrated a high correlation between their electrochemical oxidation potential on the glassy carbon electrode, their activity in bioassays and an unprecedented antioxidant activity in neuronal cell culture (EC50 similar to 20 nM) making electrochemical methodology a valuable tool in drug design for Alzheimer's and related diseases.

引用

页码：2490 / 2491

页数：2

共 21 条

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