Relationship between alcoholism and CYP2E1 C/D polymorphism

被引：22

作者：

Iwahashi, K

Ameno, S

Ameno, K

Okada, N

Kinoshita, H

Sakae, Y

Nakamura, K

Watanabe, M

Ijiri, I

Harada, S

机构：

[1] Azabu Univ, Dept Physiol, Hlth Adm Ctr, Sagamihara, Kanagawa 229, Japan

[2] Univ Tsukuba, Inst Community Med, Tsukuba, Ibaraki 305, Japan

[3] Kagawa Med Sch, Dept Neuropsychiat, Miki, Kagawa 76107, Japan

[4] Kagawa Med Sch, Dept Forens Med, Miki, Kagawa 76107, Japan

来源：

NEUROPSYCHOBIOLOGY | 1998年 / 38卷 / 04期

关键词：

CYP2E1; DraI polymorphism; alcohol dependence;

D O I：

10.1159/000026544

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The genotypes of the CYP2E1 loci of 35 alcoholic and 130 nonalcoholic (healthy controls) Japanese were investigated to determine the relationship between CYP2E1 (C/D) polymorphism and susceptibility to alcohol dependence. There was a significant (d.f. = 1, chi(2) = 11.0, p < 0.001) difference in the CYP2E1 C gene frequency between alcohol dependents (0.41) and controls (0.28), suggesting that the C gene of CYP2E1 may be related to the risk of developing alcoholism in Japanese, whereas the frequency of the D gene was higher among controls than alcoholics. Healthy Japanese controls showed a significantly (d.f. = 1, chi(2) = 30.1, p < 0.001) higher frequency of the C allele than Swedish healthy controls (0.10) did.

引用

页码：218 / 221

页数：4

共 33 条

[1] GENETIC-POLYMORPHISM OF HUMAN-LIVER ALCOHOL AND ALDEHYDE DEHYDROGENASES, AND THEIR RELATIONSHIP TO ALCOHOL METABOLISM AND ALCOHOLISM [J].