Nuclear apoptosis contributes to sarcopenia

被引：104

作者：

Alway, Stephen E. ^{[1
]}

Siu, Parco M. ^{[2
]}

机构：

[1] W Virginia Univ, Robert C Byrd Hlth Sci Ctr, Sch Med, Div Exercise Physiol,Lab Muscle Biol & Sarcopenia, Morgantown, WV 26506 USA

[2] Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Kowloon, Hong Kong, Peoples R China

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2008年 / 36卷 / 02期

关键词：

atrophy; mitochondria; skeletal myofiber; satellite cells; signaling proteins;

D O I：

10.1097/JES.0b013e318168e9dc

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Apoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia.

引用

页码：51 / 57

页数：7

共 31 条

[1] Allen DL, 1999, MUSCLE NERVE, V22, P1350, DOI 10.1002/(SICI)1097-4598(199910)22:10<1350::AID-MUS3>3.0.CO
[2] 2-8
[3] Muscle hypertrophy models: Applications for research on aging
Alway, SE
Siu, PM
Murlasits, Z
Butler, DC
[J]. CANADIAN JOURNAL OF APPLIED PHYSIOLOGY-REVUE CANADIENNE DE PHYSIOLOGIE APPLIQUEE, 2005, 30 (05): : 591 - 624
[4] Potential role for Id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats
Alway, SE
Degens, H
Krishnamurthy, G
Smith, CA
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2002, 283 (01): : C66 - C76
[5] Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy
Brack, AS
Bildsoe, H
Hughes, SM
[J]. JOURNAL OF CELL SCIENCE, 2005, 118 (20) : 4813 - 4821
[6] Distribution of myonuclei and microtubules in live muscle fibers of young, middle-aged, and old mice
Bruusgaard, J. C.
Liestol, K.
Gundersen, K.
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 2006, 100 (06) : 2024 - 2030
[7] CARSON, 1996, AM J PHYSL 1, V270, pC578
[8] Age-related alterations in expression of apoptosis regulatory proteins and heat shock proteins in rat skeletal muscle
Chung, L
Ng, YC
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2006, 1762 (01): : 103 - 109
[9] Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12
Dirks, AJ
Leeuwenburgh, C
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 2004, 36 (01) : 27 - 39
[10] Nuclear translocation of EndoG at the initiation of disuse muscle atrophy and apoptosis is specific to myonuclei
Dupont-Versteegden, Esther E.
Strotman, Beau A.
Gurley, Cathy M.
Gaddy, Dana
Knox, Micheal
Fluckey, James D.
Peterson, Charlotte A.
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2006, 291 (06) : R1730 - R1740

← 1 2 3 4 →