How far should salt intake be reduced?

被引:280
作者
He, FJ [1 ]
MacGregor, GA [1 ]
机构
[1] St George Hosp, Sch Med, Blood Pressure Unit, London SW17 0RE, England
关键词
sodium; dietary; blood pressure; dose response; cardiovascular diseases;
D O I
10.1161/01.HYP.0000102864.05174.E8
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The current public health recommendations are to reduce salt intake from 9 to 12 g/ d to 5 to 6 g/ d. However, these values are based on what is feasible rather than the maximum effect of salt reduction. In a meta- analysis of longer- term trials, we looked at the dose response between salt reduction and fall in blood pressure and compared this with 2 well- controlled studies of 3 different salt intakes. All 3 studies demonstrated a consistent dose response to salt reduction within the range of 12 to 3 g/ d. A reduction of 3 g/ d predicts a fall in blood pressure of 3.6 to 5.6/ 1.9 to 3.2 mm Hg ( systolic/ diastolic) in hypertensives and 1.8 to 3.5/ 0.8 to 1.8 mm Hg in normotensives. The effect would be doubled with a 6 g/ d reduction and tripled with a 9 g/ d reduction. A conservative estimate indicates that a reduction of 3 g/ d would reduce strokes by 13% and ischemic heart disease ( IHD) by 10%. The effects would be almost doubled with a 6 g/ d reduction and tripled with a 9 g/ d reduction. Reducing salt intake by 9 g/ d ( eg, from 12 to 3 g/ d) would reduce strokes by approximately one third and IHD by one quarter, and this would prevent approximate to 20 500 stroke deaths and 31 400 IHD deaths a year in the United Kingdom. The current recommendations to reduce salt intake from 9 to 12 g/ d to 5 to 6 g/ d will have a major effect on blood pressure and cardiovascular disease but are not ideal. A further reduction to 3 g/ d will have a much greater effect and should now become the long- term target for population salt intake worldwide.
引用
收藏
页码:1093 / 1099
页数:7
相关论文
共 48 条
[1]  
[Anonymous], 1989, CLIN EXP HYPERTENS A, V11, P1011
[2]  
[Anonymous], 2003, NATL DIET NUTR SURVE
[3]   ARTERIAL EFFECTS OF SALT RESTRICTION IN HYPERTENSIVE PATIENTS - A 9-WEEK, RANDOMIZED, DOUBLE-BLIND, CROSSOVER STUDY [J].
BENETOS, A ;
XIAO, YY ;
CUCHE, JL ;
HANNAERT, P ;
SAFAR, M .
JOURNAL OF HYPERTENSION, 1992, 10 (04) :355-360
[4]  
*BRIT HEART FDN ST, 2002, COR HEART DIS STAT
[5]   Double-blind randomised trial of modest salt restriction in older people [J].
Cappuccio, FP ;
Markandu, ND ;
Carney, C ;
Sagnella, GA ;
MacGregor, GA .
LANCET, 1997, 350 (9081) :850-854
[6]  
CHALMERS J, 1986, J HYPERTENS, V4, pS629
[7]  
CHALMERS JP, 1989, LANCET, V1, P399
[8]   A LOW-SODIUM DIET SUPPLEMENTED WITH FISH OIL LOWERS BLOOD-PRESSURE IN THE ELDERLY [J].
COBIAC, L ;
NESTEL, PJ ;
WING, LMH ;
HOWE, PRC .
JOURNAL OF HYPERTENSION, 1992, 10 (01) :87-92
[9]   Randomized trials of sodium reduction: An overview [J].
Cutler, JA ;
Follmann, D ;
Allender, PS .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1997, 65 (02) :643-651
[10]   EFFECTS OF CHRONIC EXCESS SALT INGESTION - MODIFICATION OF EXPERIMENTAL HYPERTENSION IN RAT BY VARIATIONS IN DIET [J].
DAHL, LK ;
KNUDSEN, KD ;
HEINE, MA ;
LEITL, GJ .
CIRCULATION RESEARCH, 1968, 22 (01) :11-&