The C-terminus of p53: the more you learn the less you know

被引：107

作者：

Ahn, J ^{[1
]}

Prives, C ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

NATURE STRUCTURAL BIOLOGY | 2001年 / 8卷 / 09期

关键词：

D O I：

10.1038/nsb0901-730

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NMR analyses of variants of the p53 tumor suppressor protein that either contain or lack the C-terminus reveal that the C-terminus neither interacts with other regions of p53 nor has an impact on the conformation of the rest of the molecule. Nevertheless, the C-terminus is likely to be critical for regulation of p53 function.

引用

页码：730 / 732

页数：3

共 32 条

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