Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid mixtures

被引：157

作者：

Rigoni, M

Caccin, P

Gschmeissner, S

Koster, G

Postle, AD

Rossetto, O

Schiavo, G

Montecucco, C ^{[1
]}

机构：

[1] Univ Padua, Dept Biomed Sci, I-35100 Padua, Italy

[2] Univ Padua, CNR, Inst Neurosci, I-35100 Padua, Italy

[3] Canc Res UK, London Res Inst, London, England

[4] Univ Southampton, Sch Med, Southampton SO9 5NH, Hants, England

来源：

SCIENCE | 2005年 / 310卷 / 5754期

关键词：

D O I：

10.1126/science.1120640

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Snake presynaptic phospholipase A2 neurotoxins (SPANS) paralyze the neuromuscular junction (NMJ). Upon intoxication, the NMJ enlarges and has a reduced content of synaptic vesicles, and primary neuronal cultures show synaptic swelling with surface exposure of the lumenal domain of the synaptic vesicle protein synaptotagmin I. Concomitantly, these neurotoxins induce exocytosis of neurotransmitters. We found that an equimolar mixture of lysophospholipids and fatty acids closely mimics all of the biological effects of SPANS. These results draw attention to the possible role of local lipid changes in synaptic vesicle release and provide new tools for the study of exocytosis.

引用

页码：1678 / 1680

页数：3

共 25 条

[1] Taipoxin induces synaptic vesicle exocytosis and disrupts the interaction of synaptophysin I with VAMP2 [J].