Integron-encoded GES-type extended-spectrum β-lactamase with increased activity toward aztreonam in Pseudomonas aeruginosa

被引：128

作者：

Poirel, L

Brinas, L

Fortineau, N

Nordmann, P

机构：

[1] Univ Paris 11, Hop Bicetre, Fac Med Paris Sud, Assistance Publ Hop Paris,Serv Bacteriol Virol, F-94275 Le Kremlin Bicetre, France

[2] Univ La Rioja, Area Bioquim & Biol Mol, Logrono 26006, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 08期

关键词：

D O I：

10.1128/AAC.49.8.3593-3597.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A Pseudomonas aeruginosa strain expresses an extended-spectrum beta-lactamase, GES-9, which differs from GES-1 by a Gly243Ser substitution, is inhibited by clavulanic acid and imipenem, and hydrolyzes aztreonam. The bla(GES-9) gene was located inside a class 1 integron structure containing two copies of a novel insertion sequence belonging to the IS1111 family.

引用

页码：3593 / 3597

页数：5

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