High levels of susceptibility and T helper 2 response in MyD88-deficient mice infected with Leishmania major are interleukin-4 dependent

被引：54

作者：

Debus, A ^{[1
]}

Gläsner, J ^{[1
]}

Röllinghoff, M ^{[1
]}

Gessner, A ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Inst Klin Mikrobiol Immunol & Hyg, D-91054 Erlangen, Germany

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 12期

关键词：

D O I：

10.1128/IAI.71.12.7215-7218.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myeloid differentiation protein 88 (MyD88) is a general adaptor for the signaling cascade through receptors of the Toll/IL-1R family. When infected with Leishmania major parasites, MyD88-deficient mice displayed a dramatically enhanced parasite burden in their tissues similar to that found in susceptible BALB/c mice. In contrast, MyD88 knockout mice did not develop ulcerating lesions despite a lack of interleukin-12 (IL-12) production and a predominant T helper 2 cell response. Blockade of IL-4 produced early (day 1) after infection restored a protective T helper 1 response in MyD88 knockout mice.

引用

页码：7215 / 7218

页数：4

共 27 条

[1] Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function [J].

Adachi, O ;

Kawai, T ;

Takeda, K ;

Matsumoto, M ;

Tsutsui, H ;

Sakagami, M ;

Nakanishi, K ;

Akira, S .

IMMUNITY, 1998, 9 (01) :143-150

[2] Toll-like receptors: critical proteins linking innate and acquired immunity [J].

Akira, S ;

Takeda, K ;

Kaisho, T .

NATURE IMMUNOLOGY, 2001, 2 (08) :675-680

[3]

Barton GM, 2002, CURR TOP MICROBIOL, V270, P81

[4] IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice [J].

Biedermann, T ;

Zimmermann, S ;

Himmelrich, H ;

Gumy, A ;

Egeter, A ;

Sakrauski, AK ;

Seegmüller, I ;

Voigt, H ;

Launois, P ;

Levine, AD ;

Wagner, H ;

Heeg, K ;

Louis, JA ;

Röcken, M .

NATURE IMMUNOLOGY, 2001, 2 (11) :1054-1060

[5] MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria:: No role for either in macrophage listericidal activity [J].

Edelson, BT ;

Unanue, ER .

JOURNAL OF IMMUNOLOGY, 2002, 169 (07) :3869-3875

[6] Real-time quantitative RT-PCR after laser-assisted cell picking [J].

Fink, L ;

Seeger, W ;

Ermert, L ;

Hänze, J ;

Stahl, U ;

Grimminger, F ;

Kummer, W ;

Bohle, RM .

NATURE MEDICINE, 1998, 4 (11) :1329-1333

[7] RECOMBINANT SOLUBLE INTERLEUKIN-4 (IL-4) RECEPTOR ACTS AS AN ANTAGONIST OF IL-4 IN MURINE CUTANEOUS LEISHMANIASIS [J].

GESSNER, A ;

SCHROPPEL, K ;

WILL, A ;

ENSSLE, KH ;

LAUFFER, L ;

ROLLINGHOFF, M .

INFECTION AND IMMUNITY, 1994, 62 (10) :4112-4117

[8] Prostaglandins as modulators of immunity [J].

Harris, SG ;

Padilla, J ;

Koumas, L ;

Ray, D ;

Phipps, RP .

TRENDS IN IMMUNOLOGY, 2002, 23 (03) :144-150

[9] Leishmania major activates IL-1α expression in macrophages through a MyD88-dependent pathway [J].

Hawn, TR ;

Ozinsky, A ;

Underhill, DM ;

Buckner, FS ;

Akira, S ;

Aderem, A .

MICROBES AND INFECTION, 2002, 4 (08) :763-771

[10] Underproduction of interleukin-12 in susceptible mice during progressive leishmaniasis is due to decreased CD40 activity [J].

Heinzel, FP ;

Rerko, RM ;

Hujer, AM .

CELLULAR IMMUNOLOGY, 1998, 184 (02) :129-142

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