The Human Microbiome Project in 2011 and Beyond

被引：174

作者：

Proctor, Lita M. ^{[1
]}

机构：

[1] NHGRI, NIH, Bethesda, MD 20892 USA

来源：

CELL HOST & MICROBE | 2011年 / 10卷 / 04期

关键词：

GUT MICROBIOME; INTESTINAL MICROBIOTA; BODY HABITATS; ENTEROTYPES; DISEASE; SHAPES;

D O I：

10.1016/j.chom.2011.10.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The human microbiome comprises the genes and genomes of the microbiota that inhabit the body. We highlight Human Microbiome Project (HMP) resources, including 600 microbial reference genomes, 70 million 16S sequences, 700 metagenomes, and 60 million predicted genes from healthy adult microbiomes. Microbiome studies of specific diseases and future research directions are also discussed.

引用

页码：287 / 291

页数：5

共 13 条

[1] Enterotypes of the human gut microbiome [J].

Arumugam, Manimozhiyan ;

Raes, Jeroen ;

Pelletier, Eric ;

Le Paslier, Denis ;

Yamada, Takuji ;

Mende, Daniel R. ;

Fernandes, Gabriel R. ;

Tap, Julien ;

Bruls, Thomas ;

Batto, Jean-Michel ;

Bertalan, Marcelo ;

Borruel, Natalia ;

Casellas, Francesc ;

Fernandez, Leyden ;

Gautier, Laurent ;

Hansen, Torben ;

Hattori, Masahira ;

Hayashi, Tetsuya ;

Kleerebezem, Michiel ;

Kurokawa, Ken ;

Leclerc, Marion ;

Levenez, Florence ;

Manichanh, Chaysavanh ;

Nielsen, H. Bjorn ;

Nielsen, Trine ;

Pons, Nicolas ;

Poulain, Julie ;

Qin, Junjie ;

Sicheritz-Ponten, Thomas ;

Tims, Sebastian ;

Torrents, David ;

Ugarte, Edgardo ;

Zoetendal, Erwin G. ;

Wang, Jun ;

Guarner, Francisco ;

Pedersen, Oluf ;

de Vos, Willem M. ;

Brunak, Soren ;

Dore, Joel ;

Weissenbach, Jean ;

Ehrlich, S. Dusko ;

Bork, Peer .

NATURE, 2011, 473 (7346) :174-180

[2] Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age [J].

Bisgaard, Hans ;

Li, Nan ;

Bonnelykke, Klaus ;

Chawes, Bo Lund Krogsgaard ;

Skov, Thomas ;

Paludan-Mueller, Georg ;

Stokholm, Jakob ;

Smith, Birgitte ;

Krogfelt, Karen Angeliki .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 128 (03) :646-U318

[3] Composition, variability, and temporal stability of the intestinal microbiota of the elderly [J].

Claesson, Marcus J. ;

Cusack, Siobhan ;

O'Sullivan, Orla ;

Greene-Diniz, Rachel ;

de Weerd, Heleen ;

Flannery, Edel ;

Marchesi, Julian R. ;

Falush, Daniel ;

Dinan, Timothy ;

Fitzgerald, Gerald ;

Stanton, Catherine ;

van Sinderen, Douwe ;

O'Connor, Michael ;

Harnedy, Norma ;

O'Connor, Kieran ;

Henry, Colm ;

O'Mahony, Denis ;

Fitzgerald, Anthony P. ;

Shanahan, Fergus ;

Twomey, Cillian ;

Hill, Colin ;

Ross, R. Paul ;

O'Toole, Paul W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 :4586-4591

[4] Bacterial Community Variation in Human Body Habitats Across Space and Time [J].

Costello, Elizabeth K. ;

Lauber, Christian L. ;

Hamady, Micah ;

Fierer, Noah ;

Gordon, Jeffrey I. ;

Knight, Rob .

SCIENCE, 2009, 326 (5960) :1694-1697

[5] Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa [J].

De Filippo, Carlotta ;

Cavalieri, Duccio ;

Di Paola, Monica ;

Ramazzotti, Matteo ;

Poullet, Jean Baptiste ;

Massart, Sebastien ;

Collini, Silvia ;

Pieraccini, Giuseppe ;

Lionetti, Paolo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (33) :14691-14696

[6] Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns [J].

Dominguez-Bello, Maria G. ;

Costello, Elizabeth K. ;

Contreras, Monica ;

Magris, Magda ;

Hidalgo, Glida ;

Fierer, Noah ;

Knight, Rob .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (26) :11971-11975

[7] Succession of microbial consortia in the developing infant gut microbiome [J].

Koenig, Jeremy E. ;

Spor, Ayme ;

Scalfone, Nicholas ;

Fricker, Ashwana D. ;

Stombaugh, Jesse ;

Knight, Rob ;

Angenent, Largus T. ;

Ley, Ruth E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 :4578-4585

[8] Reshaping the gut microbiome with bacterial transplantation and antibiotic intake [J].

Manichanh, Chaysavanh ;

Reeder, Jens ;

Gibert, Prudence ;

Varela, Encarna ;

Llopis, Marta ;

Antolin, Maria ;

Guigo, Roderic ;

Knight, Rob ;

Guarner, Francisco .

GENOME RESEARCH, 2010, 20 (10) :1411-1419

[9] The gut microbiota shapes intestinal immune responses during health and disease [J].

Round, June L. ;

Mazmanian, Sarkis K. .

NATURE REVIEWS IMMUNOLOGY, 2009, 9 (05) :313-323

[10] Gastrointestinal Microbiome Signatures of Pediatric Patients With Irritable Bowel Syndrome [J].

Saulnier, Delphine M. ;

Riehle, Kevin ;

Mistretta, Toni-Ann ;

Diaz, Maria-Alejandra ;

Mandal, Debasmita ;

Raza, Sabeen ;

Weidler, Erica M. ;

Qin, Xiang ;

Coarfa, Cristian ;

Milosavljevic, Aleksandar ;

Petrosino, Joseph F. ;

Highlander, Sarah ;

Gibbs, Richard ;

Lynch, Susan V. ;

Shulman, Robert J. ;

Versalovic, James .

GASTROENTEROLOGY, 2011, 141 (05) :1782-1791

← 1 2 →