Planar polarity from flies to vertebrates

被引：165

作者：

Fanto, M ^{[1
]}

McNeill, H ^{[1
]}

机构：

[1] Canc Res UK, London WC2A 3PX, England

来源：

JOURNAL OF CELL SCIENCE | 2004年 / 117卷 / 04期

关键词：

PCP; planar cell polarity; frizzled; dishevelled;

D O I：

10.1242/jcs.00973

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Planar cell polarity (PCP) has been demonstrated in the epithelium of organisms from flies to humans. Recent research has revealed that the planar organization of cells requires a conserved set of genes, known as the PCP genes. The PCP proteins Frizzled (Fz) and Dishevelled (Dsh) function as key players in PCP signalling. Although Fz and Dsh are also involved in Wingless (Wg)/Wnt signalling, these proteins have independent functions in a non-canonical pathway dedicated to PCP. Reorganization of the cell surface and cytoskeleton is required, and recent work has focused on how cell adhesion molecules (such as Fat, Dachsous and Flamingo) function in this process.

引用

页码：527 / 533

页数：7

共 59 条

[1] The domineering non-autonomy of frizzled and Van Gogh clones in the Drosophila wing is a consequence of a disruption in local signaling [J].