ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal

被引：374

作者：

Choi, Cheol-Hee ^{[1
]}

机构：

[1] Chosun Univ, Sch Med, Res Ctr Resistant Cells, Kwangju 501759, South Korea

来源：

CANCER CELL INTERNATIONAL | 2005年 / 5卷 / 1期

关键词：

ABC transporter; Bioavailability; Breast cancer resistance protein; Chemosensitizer; Drug resistance; Multidrug resistance associated protein; P-glycoprotein;

D O I：

10.1186/1475-2867-5-30

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One of the major problems related with anticancer chemotherapy is resistance against anticancer drugs. The ATP-binding cassette (ABC) transporters are a family of transporter proteins that are responsible for drug resistance and a low bioavailability of drugs by pumping a variety of drugs out cells at the expense of ATP hydrolysis. One strategy for reversal of the resistance of tumor cells expressing ABC transporters is combined use of anticancer drugs with chemosensitizers. In this review, the physiological functions and structures of ABC transporters, and the development of chemosensitizers are described focusing on well-known proteins including P-glycoprotein, multidrug resistance associated protein, and breast cancer resistance protein.

引用

页数：13

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