Visual P3a in male alcoholics and controls

被引:46
作者
Holguin, SR
Porjesz, B
Chorlian, DB
Polich, J
Begleiter, H
机构
[1] SUNY Hlth Sci Ctr, Dept Psychiat, Brooklyn, NY 11203 USA
[2] Univ Santiago de Compostela, Dept Clin Psychol & Psychobiol, Galicia, Spain
[3] Scripps Res Inst, Dept Neuropharmacol, La Jolla, CA USA
关键词
alcoholism; visual event-related potentials (ERPs; P300; P3a; current source density (CSD;
D O I
10.1097/00000374-199904001-00003
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
The goal of this study was to assess the P3a component of event-related potentials in a population of abstinent, chronic alcoholics. A three-stimulus visual oddball paradigm was used to elicit robust P3a components in a large group of well-characterized male alcoholics (n = 44) and controls (n = 28). The task required subjects to make a difficult perceptual discrimination between randomly presented, frequently occurring vertical lines (.80) and infrequent target lines that were tilted 2 degrees to the right of vertical (.10) by only responding with a button press to the target stimuli. A nontarget infrequent horizontal line occurred (.10) randomly to which no response was made. The target stimulus elicited robust late P3b components with a parietal maximum amplitude, and the nontarget stimulus elicited reliable P3a components with a fronto-central maximum amplitude distribution. Group differences in P3a were assessed using repeated measures ANCOVA analyses in five scalp regions. Alcoholic subjects produced smaller P3a amplitudes over the central, parietal, temporal, and occipital areas compared with controls. Current source density analyses supported these findings with extension of the differences between the groups to the frontal region. The results suggest that the P3a may be important in the evaluation of alcoholism and its heritability. Theoretical implications are discussed.
引用
收藏
页码:582 / 591
页数:10
相关论文
共 89 条
[1]   NEUROPSYCHOLOGICAL DEFICITS ARE CORRELATED WITH FRONTAL HYPOMETABOLISM IN POSITRON EMISSION TOMOGRAPHY STUDIES OF OLDER ALCOHOLIC PATIENTS [J].
ADAMS, KM ;
GILMAN, S ;
KOEPPE, RA ;
KLUIN, KJ ;
BRUNBERG, JA ;
DEDE, D ;
BERENT, S ;
KROLL, PD .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1993, 17 (02) :205-210
[2]  
ALMASY L, IN PRESS NEUROPSYCHI
[3]  
[Anonymous], 1994, J Clin Neurophysiol, V11, P111
[4]  
[Anonymous], J PSYCHOPHYSIOLOGY
[5]   INTRACEREBRAL POTENTIALS TO RARE TARGET AND DISTRACTER AUDITORY AND VISUAL-STIMULI .3. FRONTAL-CORTEX [J].
BAUDENA, P ;
HALGREN, E ;
HEIT, G ;
CLARKE, JM .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1995, 94 (04) :251-264
[6]   NEURORADIOLOGICAL AND NEUROPHYSIOLOGICAL EVIDENCE OF BRAIN DEFICITS IN CHRONIC-ALCOHOLICS [J].
BEGLEITER, H ;
PORJESZ, B ;
TENNER, M .
ACTA PSYCHIATRICA SCANDINAVICA, 1980, 62 :3-13
[7]  
BEGLEITER H, 1995, ALCOHOL ALCOHOLISM, V1, P269
[8]   DELAYED P3A IN ABSTINENT ELDERLY MALE CHRONIC-ALCOHOLICS [J].
BIGGINS, CA ;
MACKAY, S ;
POOLE, N ;
FEIN, G .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1995, 19 (04) :1032-1042
[9]   Event-related potential evidence for frontal cortex effects of chronic cocaine dependence [J].
Biggins, CA ;
MacKay, S ;
Clark, W ;
Fein, G .
BIOLOGICAL PSYCHIATRY, 1997, 42 (06) :472-485
[10]   SLOW POTENTIALS OF THE CEREBRAL-CORTEX AND BEHAVIOR [J].
BIRBAUMER, N ;
ELBERT, T ;
CANAVAN, AGM ;
ROCKSTROH, B .
PHYSIOLOGICAL REVIEWS, 1990, 70 (01) :1-41