Comet assay to evaluate DNA damage caused by magnetic fields

被引：12

作者：

Ahuja, YR ^{[1
]}

Bhargava, A ^{[1
]}

Sircar, S ^{[1
]}

Rizwani, W ^{[1
]}

Lima, S ^{[1
]}

Devadas, AH ^{[1
]}

Bhargava, SC ^{[1
]}

机构：

[1] Bhagwan Mahavir Med Res Ctr, Genet Unit, Hyderabad 500004, Andhra Pradesh, India

来源：

PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON ELECTROMAGNETIC INTERFERENCE AND COMPATIBILITY '97 | 1997年

关键词：

D O I：

10.1109/ICEMIC.1997.669812

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Six female subjects, in the age group of 20-25 years, were included in the study. Peripheral blood was collected from each of the 6 subjects and exposed for one hr to 5 different magnetic densities (2mT, 3mT, 5mT, 7mT, 10mT, rms) at 50 Hz in addition to the control. The blood samples were processed for comet assay. The length of comet-tail gives an estimate of DNA damage. Comet-tail length war measured in 50 cells per treatment per individual, The data were pooled for 6 subjects for each flux density of magnetic field tested. When compared with the control value, there was a significant increase in the DNA damage for each flux density. Since an increase in genomic instability is an indicator of deleterious effects on health, it may be concluded that a chronic exposure to the doses used in the present study may result in an increased incidence of congenital malformations and cancer.

引用

页码：273 / 276

页数：4