Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence

被引：88

作者：

Choi, In Young ^{[1
,2
]}

Lee, Changhan ^{[1
]}

Longo, Valter D. ^{[1
,3
,4
,5
]}

机构：

[1] Univ Southern Calif, Leonard Davis Sch Gerontol, Longev Inst, 3715 McClintock Ave, Los Angeles, CA 90089 USA

[2] Univ Calif Los Angeles, Dept Microbiol, Immunol, Mol Genet, Los Angeles, CA 90095 USA

[3] Univ Southern Calif, Dana & David Dornsife Coll Letters Arts & Sci, Dept Neurosci, Los Angeles, CA 90089 USA

[4] Univ Southern Calif, Keck Sch Med, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA 90089 USA

[5] FIRC Inst Mol Oncol, IFOM, I-20139 Milan, Italy

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2017年 / 455卷 / 0C期

关键词：

Immunosenescence; Autoimmune diseases; Metabolism; Aging; Fasting; Fasting mimicking diet; DEPENDENT DIABETES-MELLITUS; T-LYMPHOCYTE ACTIVATION; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; CALORIC RESTRICTION; LIFE-SPAN; VEGETARIAN DIET; CHRONIC INFLAMMATION; GLUCOSE-METABOLISM; OXIDATIVE STRESS;

D O I：

10.1016/j.mce.2017.01.042

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Complex and coordinated signals are necessary to initiate and sustain the activation, proliferation, and differentiation of lymphocytes. These signals, which are known to determine T-cell fate and function, also depend on the metabolic state of the organism. Recent studies indicate that both the type and levels of nutrients can influence the generation, survival and function of lymphocytes and therefore can affect several autoimmune diseases. Here, we review the dysregulation of lymphocytes during autoimmunity and aging, the mechanisms associated with loss of immune function, and how fasting mimicking diets and other dietary interventions affect autoimmunity and immunosenescence. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：4 / 12

页数：9

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