Clinical relevance of dual-energy X-ray absorptiometry (DXA) as a simultaneous evaluation of fatty liver disease and atherosclerosis in patients with type 2 diabetes

被引：25

作者：

Bouchi, Ryotaro ^{[1
]}

Nakano, Yujiro ^{[1
]}

Ohara, Norihiko ^{[1
]}

Takeuchi, Takato ^{[1
]}

Murakami, Masanori ^{[1
]}

Asakawa, Masahiro ^{[1
]}

Sasahara, Yuriko ^{[1
]}

Numasawa, Mitsuyuki ^{[1
]}

Minami, Isao ^{[1
]}

Izumiyama, Hajime ^{[1
,2
]}

Hashimoto, Koshi ^{[1
,3
]}

Yoshimoto, Takanobu ^{[1
]}

Ogawa, Yoshihiro ^{[1
,4
]}

机构：

[1] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Mol Endocrinol & Metab, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138510, Japan

[2] Tokyo Med & Dent Univ, Ctr Med Welf & Liaison Serv, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138510, Japan

[3] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Preempt Med & Metab, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138510, Japan

[4] Japan Agcy Med Res & Dev, CREST, Chiyoda Ku, 1-7-1 Otemachi, Tokyo 1000004, Japan

来源：

CARDIOVASCULAR DIABETOLOGY | 2016年 / 15卷

关键词：

Andoroid-to-gynoid ratio; Visceral adiposity; Fatty liver; Atherosclerosis; Type; 2; diabetes; VISCERAL ADIPOSE-TISSUE; INCIDENT CARDIOVASCULAR-DISEASE; KOREAN SARCOPENIC OBESITY; INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; ABDOMINAL FAT; RISK-FACTORS; ASSOCIATION;

D O I：

10.1186/s12933-016-0384-7

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background: Whole body dual-energy X-ray absorptiometry (DXA) can simultaneously measure both regional fat and non-fat mass. Android-to-gynoid (A/G) ratio measured by DXA has been reported to be associated with cardiovascular risks and visceral adiposity; however, little is known regarding its relationship with fatty liver disease and atherosclerosis among patients with diabetes. This study was designed to investigate the association of android and gynoid fat mass measured by DXA with fatty liver disease and atherosclerosis in patients with type 2 diabetes. Methods: This is a cross-sectional study of 259 patients with type 2 diabetes (mean age 64 +/- 13 years; 40.2 % female). Android and gynoid fat mass (kg) were measured by DXA. Skeletal muscle index (SMI) was calculated as appendicular non-fat mass (kg) divided by height (m(2)). Visceral fat area (VFA, cm(2)), subcutaneous fat area (SFA, cm(2)), and liver attenuation index (LAI) were assessed by abdominal computed tomography. Intima media thickness (IMT, mm) in common carotid arteries was determined by carotid ultrasonography. Results: A/G ratio was significantly correlated with VFA (r = 0.72, p < 0.001), SFA (r = 0.32, p < 0.001) and LAI (r = -0.26, p < 0.001). A/G ratio (standardized beta -0.223, p = 0.002) as well as VFA (standardized beta -0.226, p = 0.001) were significantly associated with LAI in the univariate model. A/G ratio remained to be significantly associated with LAI (standardized beta -0.224, p = 0.005) after adjusting for covariates including body mass index and transaminases. Among patients with low SMI (SMI < 7.0 in male and < 5.4 in female), A/G ratio was significantly associated with carotid IMT in the multivariate model (standardized beta 0.408, p = 0.014). Conclusions: DXA can be used to simultaneously estimate the risks for both fatty liver disease and atherosclerosis in patients with type 2 diabetes.

引用

页数：9

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