Association of AIM, a novel apoptosis inhibitory factor, with hepatitis via supporting macrophage survival and enhancing phagocytotic function of macrophages
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作者:
Haruta, I
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机构:Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
Haruta, I
Kato, Y
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机构:Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
Kato, Y
Hashimoto, E
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机构:Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
Hashimoto, E
Minjares, C
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机构:Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
Minjares, C
Kennedy, S
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机构:Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
Kennedy, S
Uto, H
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机构:Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
Uto, H
Yamauchi, K
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机构:Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
Yamauchi, K
Kobayashi, M
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机构:Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
Kobayashi, M
Yusa, S
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机构:Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
Yusa, S
Müller, U
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机构:Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
Müller, U
Hayashi, N
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机构:Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
Hayashi, N
Miyazaki, T
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机构:Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
Miyazaki, T
机构:
[1] Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
[2] Tokyo Womens Med Univ, Inst Gastroenterol, Shinjuku Ku, Tokyo 1628666, Japan
[3] Tokyo Womens Med Univ, Dept Pathol, Shinjuku Ku, Tokyo 1628666, Japan
[4] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
A hallmark of many inflammatory diseases is the destruction of tissue cells by infiltrating hematopoietic cells including lymphocytes, neutrophils, and macrophages. The regulation of apoptosis of both target tissue cells and the infiltrating cells is one of the key events that defines the initiation and the progression of inflammation. However, the precise picture of the apoptosis regulation of the cells at the inflammatory sites is still unclear. We recently isolated a novel apoptosis inhibitory factor, termed AIM, which is secreted exclusively by tissue macrophages. In this report, we present unique characteristics of AIM associated with liver inflammation (hepatitis), identified by introducing an experimental hepatitis in both AIM transgenic mice, which overexpress AIM in the body, and normal mice. First, endogenous AIM expression in macrophages is rapidly increased in response to inflammatory stimuli. Second, AIM appears to inhibit the death of macrophages in the inflammatory regions, judging by the remarkably increased number of macrophages observed in the liver from transgenic mice. In addition, we show that AIM also enhances the phagocytosis by macrophages, which emphasizes the multifunctional character of ATM. All these findings strongly provoke an idea that ATM may play an important role in hepatitis pathogenesis in a sequential manner; first AIM expression is up-regulated by inflammatory stimuli, and then in an autocrine fashion, AIM supports the survival of infiltrating macrophages as well as enhances phagocytosis by macrophages, which may result in an efficient clearance of dead cells and infectious or toxic reagents.
机构:Inst. Genet. Biol. Molec. et Cell., Ctr. Natl. de la Rech. Scientifique, Université Louis Pasteur 1, 67404 Illkirch, C.U. de Strasbourg, rue Laurent Fries
Andre, I
Gonzalez, A
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机构:Inst. Genet. Biol. Molec. et Cell., Ctr. Natl. de la Rech. Scientifique, Université Louis Pasteur 1, 67404 Illkirch, C.U. de Strasbourg, rue Laurent Fries
Gonzalez, A
Wang, B
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机构:Inst. Genet. Biol. Molec. et Cell., Ctr. Natl. de la Rech. Scientifique, Université Louis Pasteur 1, 67404 Illkirch, C.U. de Strasbourg, rue Laurent Fries
Wang, B
Katz, J
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机构:Inst. Genet. Biol. Molec. et Cell., Ctr. Natl. de la Rech. Scientifique, Université Louis Pasteur 1, 67404 Illkirch, C.U. de Strasbourg, rue Laurent Fries
Katz, J
Benoist, C
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机构:Inst. Genet. Biol. Molec. et Cell., Ctr. Natl. de la Rech. Scientifique, Université Louis Pasteur 1, 67404 Illkirch, C.U. de Strasbourg, rue Laurent Fries
Benoist, C
Mathis, D
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机构:Inst. Genet. Biol. Molec. et Cell., Ctr. Natl. de la Rech. Scientifique, Université Louis Pasteur 1, 67404 Illkirch, C.U. de Strasbourg, rue Laurent Fries
机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Med,Div Mol Oncol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Med,Div Mol Oncol, St Louis, MO 63110 USA
Chao, DT
Korsmeyer, SJ
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机构:Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Med,Div Mol Oncol, St Louis, MO 63110 USA
机构:Inst. Genet. Biol. Molec. et Cell., Ctr. Natl. de la Rech. Scientifique, Université Louis Pasteur 1, 67404 Illkirch, C.U. de Strasbourg, rue Laurent Fries
Andre, I
Gonzalez, A
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机构:Inst. Genet. Biol. Molec. et Cell., Ctr. Natl. de la Rech. Scientifique, Université Louis Pasteur 1, 67404 Illkirch, C.U. de Strasbourg, rue Laurent Fries
Gonzalez, A
Wang, B
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机构:Inst. Genet. Biol. Molec. et Cell., Ctr. Natl. de la Rech. Scientifique, Université Louis Pasteur 1, 67404 Illkirch, C.U. de Strasbourg, rue Laurent Fries
Wang, B
Katz, J
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机构:Inst. Genet. Biol. Molec. et Cell., Ctr. Natl. de la Rech. Scientifique, Université Louis Pasteur 1, 67404 Illkirch, C.U. de Strasbourg, rue Laurent Fries
Katz, J
Benoist, C
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机构:Inst. Genet. Biol. Molec. et Cell., Ctr. Natl. de la Rech. Scientifique, Université Louis Pasteur 1, 67404 Illkirch, C.U. de Strasbourg, rue Laurent Fries
Benoist, C
Mathis, D
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机构:Inst. Genet. Biol. Molec. et Cell., Ctr. Natl. de la Rech. Scientifique, Université Louis Pasteur 1, 67404 Illkirch, C.U. de Strasbourg, rue Laurent Fries
机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Med,Div Mol Oncol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Med,Div Mol Oncol, St Louis, MO 63110 USA
Chao, DT
Korsmeyer, SJ
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机构:Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Med,Div Mol Oncol, St Louis, MO 63110 USA