Endogenous oestradiol but not testosterone is related to coronary artery disease in men

被引:19
作者
Callou de Sa, Emmanuela Quental [1 ]
Feijo de Sa, Francisco Carleial [2 ]
de Souza e Silva, Rebeca [3 ]
de Oliveira, Kelly Cristina [1 ]
Guedes, Alexis Dourado [1 ]
Feres, Fausto [2 ]
do Nascimento Verreschi, Ieda Therezinha [1 ]
机构
[1] Univ Fed Sao Paulo, Dept Med, Div Endocrinol, Sao Paulo, Brazil
[2] Univ Fed Sao Paulo, Inst Dante Pazzanese Cardiol, Sao Paulo, Brazil
[3] Univ Fed Sao Paulo, Dept Prevent Med, Sao Paulo, Brazil
关键词
ESTROGEN-RECEPTOR-ALPHA; AFFECT ANDROGEN LEVELS; CARDIOVASCULAR-DISEASE; SEX-HORMONES; ELDERLY-MEN; SERUM ESTRADIOL; HEALTHY-MEN; ASSOCIATION; RISK; EXPRESSION;
D O I
10.1111/j.1365-2265.2011.04017.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives Men die of coronary artery disease (CAD) more often than women. There is evidence that testosterone either is neutral or has a beneficial effect on male cardiovascular disease. The role of oestrogens in male CAD has been less studied. This study was carried out with the purpose of evaluating the relationship between sex hormone levels and CAD. Design Case-control study. Participants Men (aged 40-70) submitted to coronary angiography. A 70% occlusion of at least one major coronary artery defined the cases; subjects with <= 50% occlusion constituted the control group. Measurements Blood samples were collected for total testosterone (TT), oestradiol, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, lipid profile and albumin measurements. Bioavailable and free testosterone, free androgen index (FAI) and free oestrogen index (FEI) were calculated. Oestradiol and TT levels were examined as terciles, based on the whole study population. Results Of the 140 patients included, 72 were cases and 68 were controls. The baseline characteristics of the two groups were similar, except for the older age and lower LDL-C in the cases. Oestradiol and FEI but not total, bioavailable and free testosterone and FAI correlated positively with CAD. After adjustments for potential confounders, oestradiol remained statistically significant. The prevalence of CAD was significantly higher in the 3rd than in the 1st tercile of oestradiol. Conclusion In this study, men with CAD had higher oestradiol and FEI levels. Additional studies are needed to clarify the direction of causality and possible underlying mechanisms.
引用
收藏
页码:177 / 183
页数:7
相关论文
共 51 条
  • [1] Serum estradiol and risk of stroke in elderly men
    Abbott, R. D.
    Launer, L. J.
    Rodriguez, B. L.
    Ross, G. W.
    Wilson, P. W. F.
    Masaki, K. H.
    Strozyk, D.
    Curb, J. D.
    Yano, K.
    Popper, J. S.
    Petrovitch, H.
    [J]. NEUROLOGY, 2007, 68 (08) : 563 - 568
  • [2] Low testosterone level as a predictor of cardiovascular events in Japanese men with coronary risk factors
    Akishita, Masahiro
    Hashimoto, Masayoshi
    Ohike, Yumiko
    Ogawa, Sumito
    Iijima, Katsuya
    Eto, Masato
    Ouchi, Yasuyoshi
    [J]. ATHEROSCLEROSIS, 2010, 210 (01) : 232 - 236
  • [3] Endogenous sex hormones and cardiovascular disease incidence in men
    Arnlov, Johan
    Pencina, Michael J.
    Amin, Shreyasee
    Nam, Byung-Ho
    Benjamin, Emelia J.
    Murabito, Joanne M.
    Wang, Thomas J.
    Knapp, Philip E.
    D'Agostino, Ralph B., Sr.
    Bhasin, Shalendar
    Vasan, Ramachandran S.
    [J]. ANNALS OF INTERNAL MEDICINE, 2006, 145 (03) : 176 - 184
  • [4] ASSCHEMAN H, 2009, 91 ANN M END SOC WAS
  • [5] Estradiol increases platelet aggregation in PlA1/A1 individuals
    Boudoulas, Konstantinos D.
    Montague, Christine Roos
    Goldschmidt-Clermont, Pascal J.
    Cooke, Glen E.
    [J]. AMERICAN HEART JOURNAL, 2006, 152 (01) : 136 - 139
  • [6] CHAITMAN BR, 2005, BRAUNWALDS HEART DIS, P153
  • [7] Intimal estrogen receptor (ER)β, but not ERα expression, is correlated with coronary calcification and atherosclerosis in pre- and postmenopausal women
    Christian, Rose C.
    Liu, Peter Y.
    Harrington, Sean
    Ruan, Ming
    Miller, Virginia M.
    Fitzpatrick, Lorraine A.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (07) : 2713 - 2720
  • [8] ESTROGENS IN THE TREATMENT OF PROSTATE-CANCER
    COX, RL
    CRAWFORD, ED
    [J]. JOURNAL OF UROLOGY, 1995, 154 (06) : 1991 - 1998
  • [9] DEGOUD KL, 1974, AM J CARDIOL, V33, P87
  • [10] Dunajska K, 2004, Aging Male, V7, P197