Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis

被引：83

作者：

Overeem, S

Dalmau, J

Bataller, L

Nishino, S

Mignot, E

Verschuuren, J

Lammers, GJ

机构：

[1] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands

[2] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[3] Univ Hosp La Fe, Dept Neurol, Valencia, Spain

[4] Stanford Univ, Ctr Narcolepsy, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA

来源：

NEUROLOGY | 2004年 / 62卷 / 01期

关键词：

D O I：

10.1212/01.WNL.0000101718.92619.67

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Idiopathic narcolepsy is associated with deficient hypocretin transmission. Narcoleptic symptoms have recently been described in paraneoplastic encephalitis with anti-Ma2 antibodies. The authors measured CSF hypocretin-1 levels in six patients with anti-Ma2 encephalitis, and screened for anti-Ma antibodies in patients with ideopathic narcolepsy. Anti-Ma autoantibodies were not detected in patients with idiopathic narcolepsy. Four patients with anti-Ma2 encephalitis had excessive daytime sleepiness; hypocretin-1 was not detectable in their cerebrospinal fluid, suggesting an immune-mediated hypocretin dysfunction.

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页码：138 / 140

页数：3

相关论文

共 10 条

[1]

Black JL, 2002, SLEEP, V25, P719

[2] The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias [J].

Mignot, E ;

Lammers, GJ ;

Ripley, B ;

Okun, M ;

Nevsimalova, S ;

Overeem, S ;

Vankova, J ;

Black, J ;

Harsh, J ;

Bassetti, C ;

Schrader, H ;

Nishino, S .

ARCHIVES OF NEUROLOGY, 2002, 59 (10) :1553-1562

[3] Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy [J].

Nishino, S ;

Ripley, B ;

Overeem, S ;

Nevsimalova, S ;

Lammers, GJ ;

Vankova, J ;

Okun, M ;

Rogers, W ;

Brooks, S ;

Mignot, E .

ANNALS OF NEUROLOGY, 2001, 50 (03) :381-388

[4] Narcolepsy: Clinical features, new pathophysiologic insights, and future perspectives [J].

Overeem, S ;

Mignot, E ;

van Dijk, JG ;

Lammers, GJ .

JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2001, 18 (02) :78-105

[5] A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains [J].

Peyron, C ;

Faraco, J ;

Rogers, W ;

Ripley, B ;

Overeem, S ;

Charnay, Y ;

Nevsimalova, S ;

Aldrich, M ;

Reynolds, D ;

Albin, R ;

Li, R ;

Hungs, M ;

Pedrazzoli, M ;

Padigaru, M ;

Kucherlapati, M ;

Fan, J ;

Maki, R ;

Lammers, GJ ;

Bouras, C ;

Kucherlapati, R ;

Nishino, S ;

Mignot, E .

NATURE MEDICINE, 2000, 6 (09) :991-997

[6] CSF hypocretin/orexin levels in narcolepsy and other neurological conditions [J].

Ripley, B ;

Overeem, S ;

Fujiki, N ;

Nevsimalova, S ;

Uchino, M ;

Yesavage, J ;

Di Monte, D ;

Dohi, K ;

Melberg, A ;

Lammers, GJ ;

Nishida, Y ;

Roelandse, FWC ;

Hungs, M ;

Mignot, E ;

Nishino, S .

NEUROLOGY, 2001, 57 (12) :2253-2258

[7] Molecular and clinical diversity in paraneoplastic immunity to Ma proteins [J].

Rosenfeld, MR ;

Eichen, JG ;

Wade, DF ;

Posner, JB ;

Dalmau, J .

ANNALS OF NEUROLOGY, 2001, 50 (03) :339-348

[8] The neurobiology, diagnosis, and treatment of narcolepsy [J].

Scammell, TE .

ANNALS OF NEUROLOGY, 2003, 53 (02) :154-166

[9] Reduced number of hypocretin neurons in human narcolepsy [J].

Thannickal, TC ;

Moore, RY ;

Nienhuis, R ;

Ramanathan, L ;

Gulyani, S ;

Aldrich, M ;

Cornford, M ;

Siegel, JM .

NEURON, 2000, 27 (03) :469-474

[10] A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer [J].

Voltz, R ;

Gultekin, SH ;

Rosenfeld, MR ;

Gerstner, E ;

Eichen, J ;

Posner, JB ;

Dalmau, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (23) :1788-1795