In vitro activities of two novel oxazolidinones (U100592 and U100766), a new fluoroquinolone (trovafloxacin), and dalfopristin-quinupristin against Staphylococcus aureus and Staphylococcus epidermidis

被引：45

作者：

Mulazimoglu, L

Drenning, SD

Yu, VL

机构：

[1] UNIV PITTSBURGH,DIV INFECT DIS,PITTSBURGH,PA 15213

[2] MARMARA UNIV,SCH MED,SECT INFECT DIS,ISTANBUL,TURKEY

[3] VET AFFAIRS MED CTR,PITTSBURGH,PA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 10期

关键词：

D O I：

10.1128/AAC.40.10.2428

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two oxazolidinones (U100592 and U100766), trovafloxacin, and a streptogramin combination (dalfopristin-quinupristin) were highly active in vitro against Staphylococcus aureus and Staphylococcus epidermidis, including methicillin-resistant strains. Trovafloxacin was more active than ciprofloxacin. Time-kill synergy studies demonstrated indifference for the oxazolidinones combined with vancomycin and rifampin against methicillin-resistant staphylococci. Spontaneous resistance was observed with all agents.

引用

页码：2428 / 2430

页数：3

共 8 条

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