A role for eosinophils in transplant rejection

被引：90

作者：

Goldman, M ^{[1
]}

Le Moine, A ^{[1
]}

Braun, M ^{[1
]}

Flamand, V ^{[1
]}

Abramowicz, D ^{[1
]}

机构：

[1] Free Univ Brussels, Fac Med, Expt Immunol Lab, B-1070 Brussels, Belgium

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 05期

关键词：

D O I：

10.1016/S1471-4906(01)01893-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Eosinophils release inflammatory mediators and cationic proteins that are instrumental in the pathogenesis of allergic diseases such as bronchial asthma. Here, we review experimental observations indicating that eosinophils are also involved in the rejection of a allografts. We pro pose that their role as effectors of transplant damage becomes crucial when classical pathways of rejection are inhibited and T helper 2 (Th2) cells dominate the alloimmune response.

引用

页码：247 / 251

页数：5

共 37 条

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