Transgenic mice: Models for the study of cataractogenesis - A minireview

被引：9

作者：

Bloemendal, H ^{[1
]}

Benedetti, EL ^{[1
]}

Dunia, I ^{[1
]}

机构：

[1] UNIV PARIS 07,CNRS,INST JACQUES MONOD,PARIS,FRANCE

来源：

OPHTHALMIC RESEARCH | 1996年 / 28卷

关键词：

transgenic mice; cataractogenesis; MDR3-Pgp expression; lens membrane damage; cytoskeleton distortion;

D O I：

10.1159/000267935

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Genetic manipulation followed by (over)expression of the transgene product in lens tissue results in: (I) inhibition of denucleation of lens fibers; (II) interference with lens cell differentiation; (III) cataract formation, The events reviewed are preceded by membrane damage, perturbed assembly of the IF cytoskeleton and distortion of the cytoskeleton-membrane complex.

引用

页码：1 / 7

页数：7

共 23 条

[1] TRANSGENIC MICE EXPRESSING A CONSTITUTIVELY ACTIVE RETINOIC ACID RECEPTOR IN THE LENS EXHIBIT OCULAR DEFECTS [J].