Thymic microenvironments, 3-D versus 2-D?

被引：114

作者：

van Ewijk, W

Wang, BP

Holländer, G

Kawamoto, H

Spanopoulou, E

Itoi, M

Amagai, T

Jiang, YF

Germeraad, WTV

Chen, WF

Katsura, Y

机构：

[1] Erasmus Univ, Dept Immunol, NL-3000 DR Rotterdam, Netherlands

[2] Harvard Univ, Beth Israel Hosp, Boston, MA 02215 USA

[3] Kantonsspital Basel, Dept Res Pediat Immunol, Basel, Switzerland

[4] Kyoto Univ, Chest Dis Res Inst, Dept Immunol, Kyoto 606, Japan

[5] Mt Sinai Sch Med, Howard Hughes Med Inst, Ruttenberg Canc Ctr, New York, NY USA

[6] Meiji Univ Oriental Med, Dept Immunol & Microbiol, Kyoto, Japan

[7] Univ Utrecht Hosp, Dept Immunol, Utrecht, Netherlands

[8] Beijing Med Univ, Dept Immunol, Beijing 100083, Peoples R China

来源：

SEMINARS IN IMMUNOLOGY | 1999年 / 11卷 / 01期

关键词：

thymus; microenvironments; epithelial cells; crosstalk; lympho-stromal interaction;

D O I：

10.1006/smim.1998.0158

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lympho-stromal interactions in the thymus crucially determine the fate of developing T cells. Epithelial cells, inter-digitating reticular cells, macrophages and fibroblasts all play a role in the shaping of the T cell repertoire. Recently published evidence shows that lympho-stromal interaction acts bi-directional. Developing T cell themselves, at different stages of differentiation, control the microarchitecture of thymic microenvironments, a phenomenon designated as 'crosstalk: This paper reviews experiments showing that developing T cells crosstalk to different thymic epithelial cells in a stepwise fashion. In this way, correctly organized thymic microenvironments guarantee normal thymopoiesis.

引用

页码：57 / 64

页数：8

共 27 条

[1] MORPHOGENETIC INTERACTIONS IN THE DEVELOPMENT OF THE MOUSE THYMUS GLAND [J].