Coinfection with Giardia lamblia and Clostridium difficile after use of ranitidine

被引:15
作者
Khatami, SS
Mukunda, B
Ravakhah, K
机构
[1] Huron Hosp, Dept Med, Cleveland Clin Hlth Syst, Cleveland, OH 44112 USA
[2] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA
关键词
D O I
10.1097/00000441-200402000-00007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 49-year-old man presented with a 3-week history of vomiting and diarrhea. He reported foamy stools but no blood or melena and had crampy epigastric pain. He denied usage of antibiotics. He had been taking ranitidine for intermittent epigastric pain for the last few months and noted an 11-pound weight loss during the 3 weeks before admission. Stool was positive for Clostridium difficile toxin and Giardia lamblia antigen. Cultures and occult blood tests were negative. Oral metronidazole, 500 mg 3 times a day, was administered, and the patient was hydrated. The diarrhea resolved, and patient was discharged on the fourth hospital day. Prior antibiotic therapy is the most common risk factor for C difficile colitis. This patient developed concomitant infection with C difficile and G lamblia while he used ranitidine. He had no other risk factors for these infections. Hence, we propose that ranitidine-induced hypochlorhydria predisposed this patient to the enteric infections.
引用
收藏
页码:91 / 93
页数:3
相关论文
共 25 条
[1]  
Abdel Kader S., 1998, Journal of the Egyptian Society of Parasitology, V28, P149
[2]  
Archimandritis A, 1998, J INTERN MED, V243, P251
[3]  
Awad R W, 1994, J R Coll Surg Edinb, V39, P319
[4]  
Bockus HL, 1932, AM J MED SCI, V184, P185
[5]   GIARDIASIS IN AMERICAN TRAVELERS TO SOVIET-UNION [J].
BRODSKY, RE ;
SPENCER, HC ;
SCHULTZ, MG .
JOURNAL OF INFECTIOUS DISEASES, 1974, 130 (03) :319-323
[6]  
DESAI HG, 1971, BRIT MED J, V1, P313
[7]   DIMINISHED CLOSTRIDIUM-DIFFICILE TOXIN-A SENSITIVITY IN NEWBORN RABBIT ILEUM IS ASSOCIATED WITH DECREASED TOXIN-A RECEPTOR [J].
EGLOW, R ;
POTHOULAKIS, C ;
ITZKOWITZ, S ;
ISRAEL, EJ ;
OKEANE, CJ ;
GONG, DH ;
GAO, N ;
XU, YL ;
WALKER, WA ;
LAMONT, JT .
JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (03) :822-829
[8]   GASTRIC-ACID BARRIER TO INGESTED MICROORGANISMS IN MAN - STUDIES IN-VIVO AND IN-VITRO [J].
GIANNELLA, RA ;
ZAMCHECK, N ;
BROITMAN, SA .
GUT, 1972, 13 (04) :251-+
[9]  
Harsch I A, 2001, Med Sci Monit, V7, P751
[10]  
HILL DR, 1999, TROPICAL INFECT DIS, P703