Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol

被引：194

作者：

Lee, Bomi ^{[1
,2
]}

Shin, Yong-Wook ^{[1
,2
]}

Bae, Eun-Ah ^{[1
,2
]}

Han, San-Jun ^{[1
,2
]}

Kim, Joo-Sun ^{[3
]}

Kang, Sam-Sik ^{[3
]}

Kim, Dong-Hyun ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea

[2] Kyung Hee Univ, Dept Pharmaceut Sci, Seoul 130701, South Korea

[3] Seoul Natl Univ, Inst Nat Prod, Seoul 110460, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2008年 / 31卷 / 04期

关键词：

allergy; Paeonia lactiflora; paeoniflorin; paeonol;

D O I：

10.1007/s12272-001-1177-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The root of Paeonia lactiflora PALL (PL, Family Paeoniaceae) has been used frequently as an antipyretic and anti-inflammatory agent in traditional medicines of Korea, China and Japan. To evaluate antiallergic effect of PL, we isolated its main constituents, paeoniflorin and paeonol, and evaluated in vivo their inhibitory effects against passive cutaenous anaphylaxis (PCA) reaction induced by IgE-antigen complex and scratching behaviors induced by compound 48/80. PL, paeoniflorin and paeonol potently inhibited PCA reaction and scratching behaviors in mice. Paeoniflorin exhibited the most potent inhibition against scratching behaviors and the acetic acid-induced writhing syndrome in mice. Paeonol most potently inhibited PCA reaction and mast cells degranulation. These findings suggest that PL can improve IgE-induced anaphylaxis and scratching behaviors, and may be due to the effect of its constituents, paeoniflorin and paeonol.

引用

页码：445 / 450

页数：6

共 29 条

[1]

ANTIALLERGIC EFFECTS OF TERFENADINE ON IMMEDIATE TYPE HYPERSENSITIVITY REACTIONS [J].

AKAGI, M ;

MIO, M ;

MIYOSHI, K ;

TASAKA, K .

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 1987, 9 (2-3) :257-279

[2]

Complementary and alternative interventions in asthma, allergy, and immunology [J].

Bielory, L .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2004, 93 (02) :S45-S54

[3]

Regulation of allergy by Fc receptors [J].

Bruhns, P ;

Frémont, S ;

Daëron, M .

CURRENT OPINION IN IMMUNOLOGY, 2005, 17 (06) :662-669

[4]

INHIBITION OF CALCIUM IONOPHORE (A23187)-STIMULATED HISTAMINE-RELEASE FROM RAT PERITONEAL MAST-CELLS BY AZELASTINE - IMPLICATIONS FOR ITS MODE OF ACTION [J].

CHAND, N ;

PILLAR, J ;

DIAMANTIS, W ;

PERHACH, JL ;

SOFIA, RD .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1983, 96 (3-4) :227-233

[5]

Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergeninduced airway inflammation and eosinophilia in a murine model of asthma [J].

Chen, Chih-Lung ;

Wang, Shulhn-Der ;

Zeng, Zhao-Ying ;

Lin, Kuo-Juei ;

Kao, Shung-Te ;

Tani, Thoru ;

Yu, Chun-Keung ;

Wang, Jiu-Yao .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 118 (01) :105-112

[6]

Choo MK, 2003, PLANTA MED, V69, P518, DOI 10.1055/s-2003-40653

[7]

Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia [J].

Chou, TC .

BRITISH JOURNAL OF PHARMACOLOGY, 2003, 139 (06) :1146-1152

[8]

Endothelium-dependent vasodilator effect of extract: Prepared from the roots of Paeonia lactiflora on isolated rat aorta [J].

Goto, H ;

Shimada, YK ;

Akechi, Y ;

Kohta, K ;

Hattori, M ;

Terasawa, K .

PLANTA MEDICA, 1996, 62 (05) :436-439

[9]

Heikal OA, 1997, BIOL PHARM BULL, V20, P517, DOI 10.1248/bpb.20.517

[10]

Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats [J].

Hsieh, Ching-Liang ;

Cheng, Chin-Yi ;

Tsai, Tung-Hu ;

Lin, I-hsin ;

Liu, Chung-Hsiang ;

Chiang, Su-Yin ;

Lin, Jaung-Geng ;

Lao, Chih-Jui ;

Tang, Nou-Ying .

JOURNAL OF ETHNOPHARMACOLOGY, 2006, 106 (02) :208-215

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