Subclinical thyroid disease

被引：778

作者：

Cooper, David S. ^{[1
]}

Biondi, Bernadette ^{[2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Div Endocrinol & Metab, Baltimore, MD 21287 USA

[2] Univ Naples Federico II, Dept Clin & Mol Endocrinol & Oncol, Naples, Italy

来源：

LANCET | 2012年 / 379卷 / 9821期

关键词：

CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; CARDIOVASCULAR RISK-FACTORS; INTIMA-MEDIA THICKNESS; LOW SERUM THYROTROPIN; BONE-MINERAL DENSITY; L-THYROXINE THERAPY; 5-YEAR FOLLOW-UP; QUALITY-OF-LIFE; DOUBLE-BLIND;

D O I：

10.1016/S0140-6736(11)60276-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Subclinical thyroid diseases-subclinical hyperthyroidism and subclinical hypothyroidism-are common clinical entities that encompass mild degrees of thyroid dysfunction. The clinical significance of mild thyroid overactivity and underactivity is uncertain, which has led to controversy over the appropriateness of diagnostic testing and possible treatment. In this Seminar, we discuss the definition, epidemiology, differential diagnoses, risks of progression to overt thyroid disease, potential effects on various health outcomes, and management of subclinical hyperthyroidism and subclinical hypothyroidism. Treatment recommendations are based on the degree to which thyroid-stimulating hormone concentrations have deviated from normal and underlying comorbidities. Large-scale randomised trials are urgently needed to inform how to best care for individuals with subclinical thyroid disease.

引用

页码：1142 / 1154

页数：13

共 145 条

[1] Overt and subclinical hypothyroidism complicating pregnancy [J].

Abalovich, M ;

Gutierrez, S ;

Alcaraz, G ;

Maccallini, G ;

Garcia, A ;

Levalle, O .

THYROID, 2002, 12 (01) :63-68

[2] Management of thyroid dysfunction during pregnancy and postpartum: An endocrine society clinical practice guideline [J].

Abalovich, Marcos ;

Amino, Nobuyuki ;

Barbour, Linda A. ;

Cobin, Rhoda H. ;

De Groot, Leslie J. ;

Glinoer, Daniel ;

Mandel, Susan J. ;

Stagnaro-Green, Alex .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (08) :S1-S47

[3] Incidence of hyperthyroidism in Stockholm, Sweden, 2003-2005 [J].

Abraham-Nordling, Mirna ;

Torring, Ove ;

Lantz, Mikael ;

Hallengren, Bengt ;

Ohrling, Hans ;

Lundell, Goran ;

Calissendorff, Jan ;

Jorneskog, Gun ;

Wallin, Goran .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2008, 158 (06) :823-827

[4] A randomized double-blind crossover trial to investigate the efficacy of screening for adult hypothyroidism [J].

Abu-Helalah, M. ;

Law, M. R. ;

Bestwick, J. P. ;

Monson, J. P. ;

Wald, N. J. .

JOURNAL OF MEDICAL SCREENING, 2010, 17 (04) :164-169

[5] Maternal thyroid deficiency and pregnancy complications: implications for population screening [J].

Allan, WC ;

Haddow, JE ;

Palomaki, GE ;

Williams, JR ;

Mitchell, ML ;

Hermos, RJ ;

Faix, JD ;

Klein, RZ .

JOURNAL OF MEDICAL SCREENING, 2000, 7 (03) :127-130

[6]

American Academy of Family Physicians, THYR

[7] Narrow individual variations in serum T4 and T3 in normal subjects:: A clue to the understanding of subclinical thyroid disease [J].

Andersen, S ;

Pedersen, KM ;

Bruun, NH ;

Laurberg, P .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (03) :1068-1072

[8] Hashimoto Thyroiditis: Part 2, Sonographic Analysis of Benign and Malignant Nodules in Patients With Diffuse Hashimoto Thyroiditis [J].

Anderson, Lauren ;

Middleton, William D. ;

Teefey, Sharlene A. ;

Reading, Carl C. ;

Langer, Jill E. ;

Desser, Terry ;

Szabunio, Margaret M. ;

Mandel, Susan J. ;

Hildebolt, Charles F. ;

Cronan, John J. .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2010, 195 (01) :216-222

[9]

[Anonymous], 2006, UK GUID US THYR FUNC

[10]

[Anonymous], 2006, Stedmans Medical Dictionary, V27th

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