A gene-based genetic linkage map of the collared flycatcher (Ficedula albicollis) reveals extensive synteny and gene-order conservation during 100 million years of avian evolution

被引:82
作者
Backstroem, Niclas [1 ]
Karaiskou, Nikoletta [2 ]
Leder, Erica H. [2 ]
Gustafsson, Lars [3 ]
Primmer, Craig R. [2 ]
Qvarnstroem, Anna [3 ]
Ellegren, Hans [1 ]
机构
[1] Uppsala Univ, Dept Evolutionary Biol, Evolutionary Biol Ctr, SE-75236 Uppsala, Sweden
[2] Univ Turku, Dept Biol, Div Genet & Physiol, Turku 20014, Finland
[3] Uppsala Univ, Evolutionary Biol Ctr, Dept Anim Ecol, SE-75236 Uppsala, Sweden
关键词
D O I
10.1534/genetics.108.088195
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
By taking advantage of a recently developed reference marker set for avian genome analysis we have constructed a gene-based genetic map of the collared flycatcher, an important "ecological model" for studies of life-history evolution, sexual selection, speciation and quantiative genetics. A pedigree of 322 birds from a natural population was genotyped for 384 single nucleotide polymorphisms (SNPs) from 170 protein-coding genes and 71 microsatellites. Altogether, 147 gene markers and 64 microsatellites form 33 linkage groups with a total genetic distance of 1787 cM. Male recombination rates are, on average, 22% higher than female rates (total distance 1982 vs. 1627 cM). The ability to anchor the collared flycatcher map with the chicken genome via the gene-based SNPs revealed an extraordinary degree of both synteny and gene-order conservation during avian evolution. The great majority of chicken chromosomes correspond to a single linkage group in collared flycatchers with only a few cases of inter- and intra-chromosomal rearrangements. The rate of chromosomal diversification, fissions/fusions,and inversions combined is thus considerably lower in birds (0.05/ MY) than in mammals (0.6-2.0/MY). A dearth of repeat elements, known to promote chromosomal breakage, in avian genomes may contribute to their stability. The degree of genome stability is likely to have important consequences for general evolutionary patterns and may explain, for example, the comparatively slow rate by which genetic incompatibility among lineage of birds evolves.
引用
收藏
页码:1479 / 1495
页数:17
相关论文
共 78 条
[1]   Linkage mapping of AFLP markers in a wild population of great reed warblers:: importance of heterozygosity and number of genotyped individuals [J].
Akesson, Mikael ;
Hansson, Bengt ;
Hasselquist, Dennis ;
Bensch, Staffan .
MOLECULAR ECOLOGY, 2007, 16 (11) :2189-2202
[2]   Genomics of natural bird populations: a gene-based set of reference markers evenly spread across the avian genome [J].
Backstroem, Niclas ;
Fagerberg, Sofie ;
Ellegren, Hans .
MOLECULAR ECOLOGY, 2008, 17 (04) :964-980
[3]   Genetic mapping in a natural population of collared flycatchers (Ficedula albicollis):: Conserved synteny but gene order rearrangements on the avian Z chromosome [J].
Backstrom, Niclas ;
Brandstrom, Mikael ;
Gustafsson, Lars ;
Qvarnstrom, Anna ;
Cheng, Hans ;
Ellegren, Hans .
GENETICS, 2006, 174 (01) :377-386
[4]   Hotspots of mammalian chromosomal evolution [J].
Bailey, JA ;
Baertsch, R ;
Kent, WJ ;
Haussler, D ;
Eichler, EE .
GENOME BIOLOGY, 2004, 5 (04)
[5]   Mapping quantitative trait loci underlying fitness-related traits in a free-living sheep population [J].
Beraldi, Dario ;
McRae, Allan F. ;
Gratten, Jacob ;
Slate, Jon ;
Visscher, Peter M. ;
Pemberton, Josephine M. .
EVOLUTION, 2007, 61 (06) :1403-1416
[6]   Contrasting patterns of polymorphism and divergence on the Z chromosome and autosomes in two Ficedula flycatcher species [J].
Borge, T ;
Webster, MT ;
Andersson, G ;
Saetre, GP .
GENETICS, 2005, 171 (04) :1861-1873
[7]   Comparative architectures of mammalian and chicken genomes reveal highly variable rates of genomic rearrangements across different lineages [J].
Bourque, G ;
Zdobnov, EM ;
Bork, P ;
Pevzner, PA ;
Tesler, G .
GENOME RESEARCH, 2005, 15 (01) :98-110
[8]   Comprehensive human genetic maps: Individual and sex-specific variation in recombination [J].
Broman, KW ;
Murray, JC ;
Sheffield, VC ;
White, RL ;
Weber, JL .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 63 (03) :861-869
[9]   The dynamics of chromosome evolution in birds and mammals [J].
Burt, DW ;
Bruley, C ;
Dunn, IC ;
Jones, CT ;
Ramage, A ;
Law, AS ;
Morrice, DR ;
Paton, IR ;
Smith, J ;
Windsor, D ;
Sazanov, A ;
Fries, R ;
Waddington, D .
NATURE, 1999, 402 (6760) :411-413
[10]   Chromosomes and speciation in Mus musculus domesticus [J].
Capanna, E ;
Castiglia, R .
CYTOGENETIC AND GENOME RESEARCH, 2004, 105 (2-4) :375-384