Cohesin and CTCF: cooperating to control chromosome conformation?

被引：35

作者：

Gause, Maria ^{[1
]}

Schaaf, Cheri A. ^{[1
]}

Dorsett, Dale ^{[1
]}

机构：

[1] St Louis Univ, Sch Med, Edward A Doisy Dept Biochem & Mol Biol, St Louis, MO 63104 USA

来源：

BIOESSAYS | 2008年 / 30卷 / 08期

关键词：

D O I：

10.1002/bies.20787

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cohesin complex is best known for its role in sister chromatid cohesion. Over the past few years, it has become apparent that cohesin also regulates gene expression, but the mechanisms by which it does so are unknown. Recently, three groups mapped numerous cohesin-binding sites in mammalian chromosomes and found substantial overlap with the CCCTC-binding factor (CTCF).((1-3)) CTCF is an insulator protein that blocks enhancer-promoter interactions, and the investigators found that cohesin also contributes to this activity. Thus, these studies demonstrate at least one mechanism by which cohesin can control gene expression.

引用

页码：715 / 718

页数：4

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