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Leaky gut and diabetes mellitus: what is the link?

被引：182
作者：
de Kort, S. [1 ]
Keszthelyi, D. [1 ]
Masclee, A. A. M. [1 ]
机构：
[1] Maastricht Univ, Med Ctr, Div Gastroenterol Hepatol, Dept Internal Med, NL-6202 AZ Maastricht, Netherlands
来源：
OBESITY REVIEWS | 2011年 / 12卷 / 06期
关键词：
Barrier function; diabetes mellitus; gastrointestinal tract; insulin resistance; INCREASED INTESTINAL PERMEABILITY; GLUCAGON-LIKE PEPTIDE-2; TREATMENT PARTIALLY PROTECTS; GLUTEN-FREE; INSULIN-RESISTANCE; INTERFERON-GAMMA; BARRIER FUNCTION; PRONE RAT; OBESITY; DIET;
D O I：
10.1111/j.1467-789X.2010.00845.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
P>Diabetes mellitus is a chronic disease requiring lifelong medical attention. With hundreds of millions suffering worldwide, and a rapidly rising incidence, diabetes mellitus poses a great burden on healthcare systems. Recent studies investigating the underlying mechanisms involved in disease development in diabetes point to the role of the dys-regulation of the intestinal barrier. Via alterations in the intestinal permeability, intestinal barrier function becomes compromised whereby access of infectious agents and dietary antigens to mucosal immune elements is facilitated, which may eventually lead to immune reactions with damage to pancreatic beta cells and can lead to increased cytokine production with consequent insulin resistance. Understanding the factors regulating the intestinal barrier function will provide important insight into the interactions between luminal antigens and immune response elements. This review analyses recent advances in the mechanistic understanding of the role of the intestinal epithelial barrier function in the development of type 1 and type 2 diabetes. Given our current knowledge, we may assume that reinforcing the intestinal barrier can offer and open new therapeutic horizons in the treatment of type 1 and type 2 diabetes.
引用
收藏
页码：449 / 458
页数：10
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