Immune response to Aβ-peptides in peripheral blood from patients with Alzheimer's disease and control subjects

被引：35

作者：

Baril, L

Nicolas, L

Croisile, B

Crozier, P

Hessler, C

Sassolas, A

McCormick, JB

Trannoy, E

机构：

[1] Hop Neurol & Neurochirurg P Wertheimer, Biochem Lab, F-69003 Lyon, France

[2] Hop Neurol & Neurochirurg P Wertheimer, Neuropsychol Lab, F-69003 Lyon, France

[3] Aventis Pasteur, Immunol Res, F-69280 Marcy Letoile, France

[4] Aventis Pasteur, Epidemiol Global Med Affairs, F-69007 Lyon, France

来源：

NEUROSCIENCE LETTERS | 2004年 / 355卷 / 03期

关键词：

Alzheimer's disease; immune response; amyloid beta-peptides; case-control study;

D O I：

10.1016/j.neulet.2003.10.071

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the immune response to amyloid beta-peptide (Abeta: Abeta(40) and Abeta(42)) in peripheral human blood, sera were obtained from 36 patients with Alzheimer's disease (AD) and 34 age-matched controls. ELISA assays were used to measure antibody concentrations to Abeta-peptides. T cell response was assessed using a lymphoproliferation assay. Both AD and control subjects had low and variable concentrations of antibodies against Abeta (predominantly IgG1). The mean antibody to Abeta concentrations did not differ between groups. No specific T cell response to Abeta-peptides was detected. Natural levels of antibodies to Abeta in peripheral blood are present in all human subjects and are unlikely to be useful in the identification of patients who would respond to potential AD immune therapy. Specific cellular immune responses to Abeta in human blood were not detected. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：226 / 230

页数：5

共 23 条

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