Behavioral phenotyping strategies for mutant mice

被引：351

作者：

Crawley, Jacqueline N. ^{[1
]}

机构：

[1] NIMH, Lab Behav Neurosci, Intramural Res Program, Bethesda, MD 20892 USA

来源：

NEURON | 2008年 / 57卷 / 06期

关键词：

D O I：

10.1016/j.neuron.2008.03.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Comprehensive behavioral analyses of transgenic and knockout mice have successfully identified the functional roles of many genes in the brain. Over the past 10 years, strategies for mouse behavioral phenotyping have evolved to maximize the scope and replicability of findings from a cohort of mutant mice, minimize the interpretation of procedural artifacts, and provide robust translational tools to test hypotheses and develop treatments. This Primer addresses experimental design issues and offers examples of high-throughput batteries, learning and memory tasks, and anxiety-related tests.

引用

页码：809 / 818

页数：10

共 133 条

[1]

Altered sensorimotor development in a transgenic mouse model of amyotrophic lateral sclerosis [J].

Amendola, J ;

Verrier, B ;

Roubertoux, P ;

Durand, J .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2004, 20 (10) :2822-2826

[2]

Transgenic and knockout databases: Behavioral profiles of mouse mutants [J].

Anagnostopoulos, AV ;

Mobraaten, LE ;

Sharp, JJ ;

Davisson, MT .

PHYSIOLOGY & BEHAVIOR, 2001, 73 (05) :675-689

[3]

Ashe KH, 2006, J ALZHEIMERS DIS, V9, P123

[4]

Establishment and chimera analysis of 129/SvEv- and C57BL/6-derived mouse embryonic stem cell lines [J].

Auerbach, W ;

Dunmore, JH ;

Fairchild-Huntress, V ;

Fang, Q ;

Auerbach, AB ;

Huszar, D ;

Joyner, AL .

BIOTECHNIQUES, 2000, 29 (05) :1024-+

[5]

Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-maze [J].

Bailey, Kathleen R. ;

Pavlova, Maria N. ;

Rohde, Alex D. ;

Hohmann, John G. ;

Crawley, Jacqueline N. .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2007, 86 (01) :8-20

[6]

Behavioral phenotyping of transgenic and knockout mice: Practical concerns and potential pitfalls [J].

Bailey, KR ;

Rustay, NR ;

Crawley, JN .

ILAR JOURNAL, 2006, 47 (02) :124-131

[7]

Atm-deficient mice: A paradigm of ataxia telangiectasia [J].

Barlow, C ;

Hirotsune, S ;

Paylor, R ;

Liyanage, M ;

Eckhaus, M ;

Collins, F ;

Shiloh, Y ;

Crawley, JN ;

Ried, T ;

Tagle, D ;

WynshawBoris, A .

CELL, 1996, 86 (01) :159-171

[8]

Intramaze and extramaze cue processing in adult APPSWE Tg2576 transgenic mice [J].

Barnes, P ;

Hale, G ;

Good, M .

BEHAVIORAL NEUROSCIENCE, 2004, 118 (06) :1184-1195

[9]

BARRETT, 2003, CURR PROTOCOLS NEURO, V8, P1

[10]

Bilbo SD, 2001, LAB ANIMAL, V30, P24

← 1 2 3 4 5 6 7 8 9 10 →