Direct evidence for epithelial-mesenchymal transitions in breast cancer

被引：286

作者：

Trimboli, Anthony J. ^{[1
,2
,3
]}

Fukino, Koichi ^{[2
,3
]}

de Bruin, Alain ^{[1
,2
,3
]}

Wei, Guo ^{[1
,2
,3
]}

Shen, Lei ^{[4
]}

Tanner, Stephan M. ^{[2
,3
]}

Creasap, Nicholas ^{[1
,2
,3
]}

Rosol, Thomas J. ^{[5
]}

Robinson, Michael L. ^{[6
]}

Eng, Charis ^{[1
,2
,3
,7
,8
]}

Ostrowski, Michael C. ^{[1
,2
,3
]}

Leone, Gustavo ^{[1
,2
,3
]}

机构：

[1] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA

[2] Ohio State Univ, Human Canc Genet Program, Ctr Comprehens Canc, Columbus, OH 43210 USA

[3] Ohio State Univ, Coll Med, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[4] Ohio State Univ, Sch Publ Hlth, Div Epidemiol & Biostat, Columbus, OH 43210 USA

[5] Ohio State Univ, Dept Vet Biosci, Columbus, OH 43210 USA

[6] Columbus Childrens Res Inst, Ctr Childhood Canc, Columbus, OH USA

[7] Case Western Reserve Univ, Sch Med, Gen Med Inst, Cleveland Clin Lerner Res Inst, Cleveland, OH 44106 USA

[8] Case Western Reserve Univ, Sch Med, Dept Genet, Cleveland, OH 44106 USA

来源：

CANCER RESEARCH | 2008年 / 68卷 / 03期

关键词：

D O I：

10.1158/0008-5472.CAN-07-2148

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We developed stromal- and epithelial-specific cre-transgenic mice to directly visualize epithelial-mesenchymal transition (EMT) during cancer progression in vivo. Using three different oncogene-driven mouse mammary tumor models and cell-fate mapping strategies, we show in vivo evidence for the existence of EMT in breast cancer and show that myc can specifically elicit this process. Hierarchical cluster analysis of genome-wide loss of heterozygosity reveals that the incidence of EMT in invasive human breast carcinomas is rare, but when it occurs it is associated with the amplification of MYC. These data provide the first direct evidence for EMT in breast cancer and suggest that its development is favored by myc-initiated events.

引用

页码：937 / 945

页数：9

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