Early relapse after high-dose chemotherapy rescued by tumor-free autologous peripheral blood stem cells in acute lymphoblastic leukemia: Importance of monitoring for WT1-mRNA quantitatively

被引：6

作者：

Sakatani, T ^{[1
]}

Shimazaki, C ^{[1
]}

Hirai, H ^{[1
]}

Okano, A ^{[1
]}

Hatsuse, M ^{[1
]}

Okamoto, A ^{[1
]}

Takahashi, R ^{[1
]}

Ashihara, E ^{[1
]}

Inaba, T ^{[1
]}

Yokota, H ^{[1
]}

Nakahara, K ^{[1
]}

Hirai, H ^{[1
]}

Nakagawa, M ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Dept Med 2, Kamigyo Ku, Kyoto 6028566, Japan

来源：

LEUKEMIA & LYMPHOMA | 2001年 / 42卷 / 1-2期

关键词：

MLL gene; minimal residual disease (MRD); PBSCT; wilms tumor gene (WT-1);

D O I：

10.3109/10428190109097695

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 24-year-old woman who suffered from ALL with MLL gene rearrangement received high-dose chemotherapy followed by autologous PBSC transplantation during complete remission (CR). Reverse transcriptase-polymerase chain reaction (RT-PCR) used to detect MLL/LTG4 chimeric mRNA showed no minimal residual disease (MRD) in the graft or bone marrow at the transplantation. However, the leukemia relapsed four months after transplantation. Retrospective analysis of quantitative measurement of Wilms tumor gene (WT-1) mRNA showed an increased level in the bone marrow although it was within the normal range. These observations suggest that careful monitoring of MRD by quantitative measurement of WT-1 mRNA in addition to disease-specific chimeric mRNA is required to predict relapse.

引用

页码：225 / 229

页数：5

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