Evaluation of Tuberculosis Diagnostics in Children: 1. Proposed Clinical Case Definitions for Classification of Intrathoracic Tuberculosis Disease. Consensus From an Expert Panel

被引：262

作者：

Graham, Stephen M. ^{[1
,2
]}

Ahmed, Tahmeed ^{[3
]}

Amanullah, Farhana ^{[4
]}

Browning, Renee ^{[5
]}

Cardenas, Vicky ^{[6
]}

Casenghi, Martina ^{[7
]}

Cuevas, Luis E. ^{[8
]}

Gale, Marianne ^{[9
]}

Gie, Robert P. ^{[10
]}

Grzemska, Malgosia ^{[11
]}

Handelsman, Ed ^{[12
]}

Hatherill, Mark ^{[13
]}

Hesseling, Anneke C. ^{[14
]}

Jean-Philippe, Patrick ^{[5
]}

Kampmann, Beate ^{[15
,16
]}

Kabra, Sushil Kumar ^{[17
]}

Lienhardt, Christian ^{[11
]}

Lighter-Fisher, Jennifer ^{[18
]}

Madhi, Shabir ^{[19
]}

Makhene, Mamodikoe ^{[20
]}

Marais, Ben J. ^{[21
]}

McNeeley, David F. ^{[22
]}

Menzies, Heather ^{[23
]}

Mitchell, Charles ^{[24
]}

Modi, Surbhi ^{[25
]}

Mofenson, Lynne ^{[26
]}

Musoke, Philippa ^{[27
]}

Nachman, Sharon ^{[28
]}

Powell, Clydette ^{[29
]}

Rigaud, Mona ^{[18
]}

Rouzier, Vanessa ^{[30
]}

Starke, Jeffrey R. ^{[31
]}

Swaminathan, Soumya ^{[32
]}

Wingfield, Claire ^{[33
]}

机构：

[1] Univ Melbourne, Royal Childrens Hosp, Ctr Int Child Hlth, Dept Paediat & Murdoch Childrens,Res Inst, Parkville, Vic 3052, Australia

[2] Int Union TB & Lung Dis, Paris, France

[3] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh

[4] Indus Hosp, Karachi, Pakistan

[5] NIAID, Henry Jackson Fdn, Maternal Adolescent Pediat Res Branch, Div Aids,NIH, Bethesda, MD 20892 USA

[6] Aeras, Rockville, MD USA

[7] Med Sans Frontieres, Geneva, Switzerland

[8] Univ Liverpool, Sch Trop Med, Liverpool L69 3BX, Merseyside, England

[9] Med Sans Frontieres, Sydney, NSW, Australia

[10] Univ Stellenbosch, Dept Paediat & Child Hlth, Cape Town, South Africa

[11] WHO, Stop TB Partnership, CH-1211 Geneva, Switzerland

[12] NIAID, Maternal Adolescent Pediat Res Branch, Div Aids, NIH, Bethesda, MD 20892 USA

[13] Univ Cape Town, Sch Child & Adolescent Hlth, S African TB Vaccine Initiat, ZA-7925 Cape Town, South Africa

[14] Univ Stellenbosch, Desmond Tutu TB Ctr, Dept Paediat & Child Hlth, Cape Town, South Africa

[15] Univ London Imperial Coll Sci Technol & Med, Dept Paediat, London, England

[16] MRC Labs, Banjul, Gambia

[17] All India Inst Med Sci, New Delhi, India

[18] NYU, Sch Med, New York, NY USA

[19] Natl Inst Communicable Dis, Natl Hlth Lab Serv, Johannesburg, South Africa

[20] NIAID, Div Microbiol & Infect Dis, NIH, Bethesda, MD 20892 USA

[21] Univ Sydney, Childrens Hosp Westmead, Sydney, NSW 2006, Australia

[22] Med Serv Corp Int, Arlington, VA USA

[23] Ctr Dis Control & Prevent, Int Res & Programs Branch, Div TB Eliminat, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA

[24] Univ Miami, Miller Sch Med, Miami, FL 33136 USA

[25] Ctr Dis Control & Prevent, Maternal & Child Hlth Branch, Div Global HIV AIDS, Atlanta, GA USA

[26] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Pediat Adolescent & Maternal AIDS Branch, NIH, Rockville, MD USA

[27] Makerere Univ Johns Hopkins Univ Res Collaborat, Kampala, Uganda

[28] SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USA

[29] US Agcy Int Dev, Div Infect Dis, Off Hlth Infect Dis & Nutr, Bur Global Hlth, Washington, DC 20523 USA

[30] GHESKIO Ctr, Port Au Prince, Haiti

[31] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[32] Natl Inst Res TB, Chennai, Tamil Nadu, India

[33] Treatment Act Grp, New York, NY USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2012年 / 205卷

基金：

美国国家卫生研究院;

关键词：

DRUG-RESISTANT TUBERCULOSIS; XPERT MTB/RIF TEST; CHILDHOOD TUBERCULOSIS; PULMONARY TUBERCULOSIS; SOUTH-AFRICA; ACCURACY; CHALLENGES;

D O I：

10.1093/infdis/jis008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is a critical need for improved diagnosis of tuberculosis in children, particularly in young children with intrathoracic disease as this represents the most common type of tuberculosis in children and the greatest diagnostic challenge. There is also a need for standardized clinical case definitions for the evaluation of diagnostics in prospective clinical research studies that include children in whom tuberculosis is suspected but not confirmed by culture of Mycobacterium tuberculosis. A panel representing a wide range of expertise and child tuberculosis research experience aimed to develop standardized clinical research case definitions for intrathoracic tuberculosis in children to enable harmonized evaluation of new tuberculosis diagnostic technologies in pediatric populations. Draft definitions and statements were proposed and circulated widely for feedback. An expert panel then considered each of the proposed definitions and statements relating to clinical definitions. Formal group consensus rules were established and consensus was reached for each statement. The definitions presented in this article are intended for use in clinical research to evaluate diagnostic assays and not for individual patient diagnosis or treatment decisions. A complementary article addresses methodological issues to consider for research of diagnostics in children with suspected tuberculosis.

引用

页码：S199 / S208

页数：10

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